Athel Cornish-Bowden Explained

Athel Cornish-Bowden should not be confused with Athelstan Hall Cornish-Bowden (land surveyor).

Athel Cornish-Bowden
Birth Name:Athelstan John Cornish-Bowden
Birth Date:3 April 1943
Birth Place:Ashburton, England
Nationality:British, French
Fields:Biochemistry, theoretical biology
Workplaces:University of California, Berkeley, University of Birmingham, CNRS, Marseilles
Education:Oxford University
Doctoral Advisor:Jeremy R. Knowles
Thesis Title:Studies of Pepsin catalysis
Thesis Year:1967
Awards:D.Sc., Oxford, 1983; corresponding member of the Academia Chilena de Ciencias
Spouse:Mary Ann Reynolds, María de la Luz Cárdenas Cerda
Signature:Signature_of_Athel_Cornish-Bowden.jpg
Academic Advisors:Daniel E. Koshland Jr.
Known For:Enzyme Kinetics, Metabolic Control Analysis

Athel Cornish-Bowden (born 3 April 1943) is a British biochemist known for his numerous textbooks, particularly those on enzyme kinetics and his work on metabolic control analysis.

Education and career

Athel Cornish-Bowden worked on pepsin catalysis.[1] This began a life long pursuit of work on enzyme catalysis[2] and in later years work on the control of metabolism.[3] More recently he has also turned his attention to work related to the origin and nature of life.[4]

He obtained his D.Phil. at Oxford with Jeremy R. Knowles,[5] and carried out post-doctoral work with Daniel E. Koshland Jr.[6]

Research

Cornish-Bowden has authored over 200 peer-reviewed papers and nine textbooks[7] [8] on topics related to enzyme kinetics, mathematics and historical perspectives in science. According to Google Scholar, the textbook, Fundamentals of enzyme kinetics,[9] has been cited over 3000 times by secondary sources.[10]

Cornish-Bowden's research can be divided into three primary areas: Enzyme kinetics, metabolic control, done mainly in collaboration with Jannie Hofmeyr, and the origin of life. The following lists some of the topics and selected references to the work carried out and published by Cornish-Bowden:

Additionally, Cornish-Bowden has published a number of history of science papers commemorating the lives and achievements of historical figures in enzymology. [31] [32] [33] His current interests include the definition of life and the capacity for life to self-organize.

Major Research Contributions

Cornish-Bowden is most well known for his introduction of the direct-linear plot for estimating enzyme parameters,[34] his work on Hexokinase evolution and kinetics,[35] and his insight into the control and regulation of metabolism.[36]

Editorial and Related Work

Cornish-Bowden has participated on the editorial boards of various journals (the Biochemical Journal, the Journal of Theoretical Biology, FEBS Journal, BioSystems), and has been active on International Committees. He was secretary of the IUPAC-IUBMB Joint Committee on Biochemical Nomenclature[37] and in that capacity convened the committee that prepared the current IUBMB recommendations on enzyme kinetics.[38] He also contributed to recommendations on biochemical thermodynamics,[39] and to proposals for system representation of biochemical networks.[40]

Books

Fundamentals of Enzyme Kinetics

Notes and References

  1. Cornish-Bowden . AJ . Greenwell . P . Knowles . JR . The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate. . The Biochemical Journal . June 1969 . 113 . 2 . 369–75 . 10.1042/bj1130369 . 4897200. 1184644 .
  2. Cornish-Bowden . A . Connolly . BA . Gregoriou . M . Holroyde . MJ . Storer . AC . Trayer . IP . Mammalian hexokinases: a system for the study of co-operativity in monomeric enzymes. . Archivos de Biología y Medicina Experimentales . December 1979 . 12 . 5 . 581–5 . 552244.
  3. Hofmeyr . JH . Cornish-Bowden . A . Quantitative assessment of regulation in metabolic systems. . European Journal of Biochemistry . 15 August 1991 . 200 . 1 . 223–36 . 10.1111/j.1432-1033.1991.tb21071.x . 1879427. free .
  4. Cornish-Bowden . A . Cárdenas . ML . Life before LUCA. . Journal of Theoretical Biology . 7 December 2017 . 434 . 68–74 . 10.1016/j.jtbi.2017.05.023 . 28536033. 2017JThBi.434...68C .
  5. Cornish-Bowden . AJ . Greenwell . P . Knowles . JR . The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate. . The Biochemical Journal . June 1969 . 113 . 2 . 369–75 . 10.1042/bj1130369 . 4897200. 1184644 .
  6. Cornish-Bowden . A . Koshland DE . Jr . A general method for the quantitative determination of saturation curves for multisubunit proteins. . Biochemistry . 18 August 1970 . 9 . 17 . 3325–36 . 10.1021/bi00819a006 . 4330854.
  7. Silverberg . Michael . Review of Fundamentals of Enzyme Kinetics.; Analysis of Enzyme Kinetic Data. . The Quarterly Review of Biology . 1997 . 72 . 3 . 318-220. 10.1086/419873 .
  8. Patrick . Wayne . Biochemical Evolution: The Pursuit of Perfection by Athel Cornish-Bowden . The Quarterly Review of Biology . 2017 . 92 . 3 . 92–93 . 10.1086/419873 .
  9. Book: Cornish-Bowden . Athel . Fundamentals of Enzyme Kinetics . 2013 . John Wiley & Sons.
  10. Web site: Google Scholar .
  11. Cornish-Bowden . AJ . Knowles . JR . The pH-dependence of pepsin-catalysed reactions. . The Biochemical Journal . June 1969 . 113 . 2 . 353–62 . 10.1042/bj1130353 . 4897198. 1184642 .
  12. Cornish-Bowden . AJ . Greenwell . P . Knowles . JR . The rate-determining step in pepsin-catalysed reactions, and evidence against an acyl-enzyme intermediate. . The Biochemical Journal . June 1969 . 113 . 2 . 369–75 . 10.1042/bj1130369 . 4897200. 1184644 .
  13. Cornish-Bowden . A . Koshland DE . Jr . The influence of binding domains on the nature of subunit interactions in oligomeric proteins. Application to unusual kinetic and binding patterns. . The Journal of Biological Chemistry . 10 December 1970 . 245 . 23 . 6241–50 . 10.1016/S0021-9258(18)62600-6 . 5484808. free .
  14. Cornish-Bowden . A . Koshland DE . Jr . A general method for the quantitative determination of saturation curves for multisubunit proteins. . Biochemistry . 18 August 1970 . 9 . 17 . 3325–36 . 10.1021/bi00819a006 . 4330854.
  15. Cornish-Bowden . A . Koshland DE . Jr . Diagnostic uses of the Hill (Logit and Nernst) plots. . Journal of Molecular Biology . 25 June 1975 . 95 . 2 . 201–12 . 10.1016/0022-2836(75)90390-3 . 171413.
  16. Cornish-Bowden . A . Letter: The physiological significance of negative co-operativity. . Journal of Theoretical Biology . May 1975 . 51 . 1 . 233–5 . 10.1016/0022-5193(75)90149-6 . 1142781.
  17. Coleman . KJ . Cornish-Bowden . A . Cole . JA . Purification and properties of nitrite reductase from Escherichia coli K12. . The Biochemical Journal . 1 November 1978 . 175 . 2 . 483–93 . 10.1042/bj1750483 . 217342. 1186095 .
  18. Jackson . RH . Cole . JA . Cornish-Bowden . A . The steady state kinetics of the NADH-dependent nitrite reductase from Escherichia coli K12. The reduction of single-electron acceptors. . The Biochemical Journal . 1 May 1982 . 203 . 2 . 505–10 . 10.1042/bj2030505 . 6288003. 1158256 .
  19. Buc . J . Santini . CL . Blasco . F . Giordani . R . Cárdenas . ML . Chippaux . M . Cornish-Bowden . A . Giordano . G . Kinetic studies of a soluble alpha beta complex of nitrate reductase A from Escherichia coli. Use of various alpha beta mutants with altered beta subunits. . European Journal of Biochemistry . 15 December 1995 . 234 . 3 . 766–72 . 10.1111/j.1432-1033.1995.766_a.x . 8575433. free .
  20. Cornish-Bowden . A . The effect of natural selection on enzymic catalysis. . Journal of Molecular Biology . 15 February 1976 . 101 . 1 . 1–9 . 10.1016/0022-2836(76)90062-0 . 1255718.
  21. Cornish-Bowden . A . Are introns structural elements or evolutionary debris? . Nature . 1985 . 313 . 6002 . 434–5 . 10.1038/313434b0 . 3969152. free .
  22. Hofmeyr . JH . Cornish-Bowden . A . Quantitative assessment of regulation in metabolic systems. . European Journal of Biochemistry . 15 August 1991 . 200 . 1 . 223–36 . 10.1111/j.1432-1033.1991.tb21071.x . 1879427. free .
  23. Cornish-Bowden . A . Hofmeyr . JH . Determination of control coefficients in intact metabolic systems. . The Biochemical Journal . 1 March 1994 . 298 (Pt 2) . 2 . 367–75 . 10.1042/bj2980367 . 8135743. 1137949 .
  24. Hofmeyr . JH . Cornish-Bowden . A . Co-response analysis: a new experimental strategy for metabolic control analysis. . Journal of Theoretical Biology . 7 October 1996 . 182 . 3 . 371–80 . 10.1006/jtbi.1996.0176 . 8944170. 1996JThBi.182..371H .
  25. Hofmeyr . JS . Cornish-Bowden . A . Regulating the cellular economy of supply and demand. . FEBS Letters . 30 June 2000 . 476 . 1–2 . 47–51 . 10.1016/s0014-5793(00)01668-9 . 10878248. free .
  26. Cornish-Bowden . A . Hofmeyr . JH . The role of stoichiometric analysis in studies of metabolism: an example. . Journal of Theoretical Biology . 21 May 2002 . 216 . 2 . 179–91 . 10.1006/jtbi.2002.2547 . 12079370. 2002JThBi.216..179C .
  27. Cornish-Bowden . A . Cárdenas . ML . Letelier . JC . Soto-Andrade . J . Abarzúa . FG . Understanding the parts in terms of the whole. . Biology of the Cell . December 2004 . 96 . 9 . 713–7 . 10.1016/j.biolcel.2004.06.006 . 15567526. free .
  28. Cornish-Bowden . A . Cárdenas . ML . Organizational invariance in (M,R)-systems. . Chemistry & Biodiversity . October 2007 . 4 . 10 . 2396–406 . 10.1002/cbdv.200790195 . 17955465. 6772968 .
  29. Cornish-Bowden . A . Cárdenas . ML . Self-organization at the origin of life. . Journal of Theoretical Biology . 7 June 2008 . 252 . 3 . 411–8 . 10.1016/j.jtbi.2007.07.035 . 17889904. 2008JThBi.252..411C .
  30. Cárdenas . ML . Letelier . JC . Gutierrez . C . Cornish-Bowden . A . Soto-Andrade . J . Closure to efficient causation, computability and artificial life. . Journal of Theoretical Biology . 7 March 2010 . 263 . 1 . 79–92 . 10.1016/j.jtbi.2009.11.010 . 19962389. 2010JThBi.263...79L . 10533/130547 . free .
  31. Cornish-Bowden . AJ . Lagnado . J . Maud Leonora Menten: A woman at the dawn of biochemistry. . The Biochemist . December 2013 . 35 . 6 . 46–47. 10.1042/BIO03506046. free .
  32. Deichmann. U . Schuster. S . Mazat . J-P . Cornish-Bowden . A . Commemorating the 1913 Michaelis–Menten paper Die Kinetik der Invertinwirkung: three perspectives. . The FEBS Journal . January 2014 . 81 . 2 . 435-463 . 10.1111/febs.12598. free .
  33. Cornish-Bowden . AJ . One hundred years of Michaelis–Menten kinetics. . Perspectives in Science . March 2015 . 4 . 3-9 . 10.1016/j.pisc.2014.12.002. free .
  34. Eisenthal . R . Cornish-Bowden . A . The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters. . The Biochemical Journal . June 1974 . 139 . 3 . 715–20 . 10.1042/bj1390715 . 4854723. 1166335 .
  35. Cárdenas . ML . Cornish-Bowden . A . Ureta . T . Evolution and regulatory role of the hexokinases. . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 5 March 1998 . 1401 . 3 . 242–64 . 10.1016/s0167-4889(97)00150-x . 9540816. free .
  36. Hofmeyr . JS . Cornish-Bowden . A . Regulating the cellular economy of supply and demand. . FEBS Letters . 30 June 2000 . 476 . 1–2 . 47–51 . 10.1016/s0014-5793(00)01668-9 . 10878248. free .
  37. Revision of Enzyme Nomenclature — Listing Enzymes . Dixon . H B F . Cornish-Bowden . A . Eur. J. Biochem. . 1983 . 133 . 3 . 479 . 10.1111/j.1432-1033.1983.tb07489.x.
  38. Arch. Biochem. Biophys. . Symbolism and terminology in enzyme kinetics: recommendations 1981. Nomenclature Committee of the International Union of Biochemistry (NC-IUB). 224 . 2 . 732–740 . 1983 . 10.1016/0003-9861(83)90262-X.
  39. 10.1016/j.bpc.2011.03.007 . Recommendations for terminology and databases for biochemical thermodynamics . Alberty . R A . Cornish-Bowden . A . Goldberg . R N . Tipton . K F . Westerhoff . H V. Biophys. Chem. . 155 . 2–3 . 89–103. 2011. 21501921 .
  40. Hucka . A. . Finney . H. M. . Sauro . H. . Bolouri . J. C. . Doyle . H.. Kitano . A. P. . etal. 2003. The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models. Bioinformatics. 19. 4 . 524–531 . 10.1093/bioinformatics/btg015 . 12611808 .

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