Ataxia-telangiectasia group D complementing explained

Ataxia-telangiectasia group D complementing (ATDC) is a gene implicated in ataxia-telangiectasia.

It is involved in a mouse model of pancreatic cancer.^{[1] [2]}

Further reading

• Brzoska PM, Chen H, Zhu Y, Levin NA, Disatnik MH, Mochly-Rosen D, Murnane JP, Christman MF . The product of the ataxia-telangiectasia group D complementing gene, ATDC, interacts with a protein kinase C substrate and inhibitor . Proc. Natl. Acad. Sci. U.S.A. . 92 . 17 . 7824–8 . 1995 . 7644499 . 41238 . 10.1073/pnas.92.17.7824 . 1995PNAS...92.7824B . free .
• Murnane JP, Zhu Y, Young BR, Christman MF . Expression of the candidate A-T gene ATDC is not detectable in a human cell line with a normal response to ionizing radiation . Int. J. Radiat. Biol. . 66 . 6 Suppl . S77-84 . 1994 . 7836856 . 10.1080/09553009414551901 .
• Laderoute KR, Knapp AM, Green CJ, Sutherland RM, Kapp LN . Expression of the ATDC (ataxia telangiectasia group D-complementing) gene in A431 human squamous carcinoma cells . Int. J. Cancer . 66 . 6 . 772–8 . 1996 . 8647648 . 10.1002/(SICI)1097-0215(19960611)66:6<772::AID-IJC11>3.0.CO;2-5 . 29088136 . free .
• Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K . Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC . Biochem. Biophys. Res. Commun. . 348 . 2 . 728–34 . 2006 . 16890201 . 10.1016/j.bbrc.2006.07.115 .
• Tauchi H, Green C, Knapp M, Laderoute K, Kapp L . Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein . Mutagenesis . 15 . 2 . 105–8 . 2000 . 10719033 . 10.1093/mutage/15.2.105 . free .

Notes and References

1. https://www.genengnews.com/news/pancreatic-cancer-halted-in-mice/ Pancreatic Cancer Halted in Mice Through Single Gene Deletion 2019
2. http://genesdev.cshlp.org/content/early/2019/04/25/gad.323303.118.abstract ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis 2019