Astrothelium trypethelioides is a species of corticolous (bark-dwelling) lichen in the family Trypetheliaceae. Found in Venezuela, it was formally described as a new species in 2016 by André Aptroot. The type specimen was collected by Harrie Sipman along the Carapo River (Bolivar) at an altitude of 800m (2,600feet). The lichen has a smooth, somewhat shiny, pale yellowish-grey thallus that covers areas of up to 9cm (04inches). Its ascospores are hyaline, spindle-shaped (fusiform) with between 7 and 9 septa and dimensions of 49–52 by 13–16 μm. No lichen products were detected in the species using thin-layer chromatography.