| Post: | United States Assistant Secretary of State for South and Central Asian Affairs |
| Insignia: | U.S. Department of State official seal.svg |
| Insigniasize: | 120px |
| Insigniacaption: | Seal of the United States Department of State |
| Incumbent: | Donald Lu |
| Incumbentsince: | September 15, 2021 |
| Reports To: | Under Secretary of State for Political Affairs |
| Nominator: | President of the United States |
| Formation: | 1992 |
| Inaugural: | Edward Djerejian |
| Website: | Official Website |
The assistant secretary of state for South and Central Asian affairs is the head of the Bureau of South and Central Asian Affairs within the United States Department of State, which handles U.S. foreign policy and relations in the following countries: Afghanistan, Bangladesh, Bhutan, India, Kyrgyzstan, Kazakhstan, Maldives, Nepal, Pakistan, Sri Lanka, Tajikistan, Turkmenistan, and Uzbekistan.
The position of Assistant Secretary of State for South Asian Affairs was renamed when responsibility for policy for five countries (Kazakhstan, Uzbekistan, Kyrgyzstan, Tajikistan, and Turkmenistan) was transferred from the Bureau of European and Eurasian Affairs to the Bureau of South Asian Affairs, which became the Bureau of South and Central Asian Affairs. Richard A. Boucher was sworn in as the first to hold the current title on February 21, 2006 after the previous Assistant Secretary, Christina B. Rocca, left the Department.
| Name | Assumed office | Left office | President served under | |
|---|---|---|---|---|
| - | Edward P. Djerejian[1] | August 24, 1992 | May 30, 1993[2] | George H. W. Bush and Bill Clinton |
| - | [3] | |||
| 1 | Robin Raphel | August 6, 1993 | June 27, 1997 | Bill Clinton |
| 2 | Karl Inderfurth | August 4, 1997 | January 19, 2001 | |
| 3 | Christina B. Rocca | June 1, 2001 | February 17, 2006 | George W. Bush |
| 4 | Richard Boucher | February 21, 2006 | January 20, 2009 | |
| 5 | Robert O. Blake, Jr. | May 26, 2009 | October 20, 2013 | Barack Obama |
| 6 | Nisha Desai Biswal | October 21, 2013 | January 20, 2017 | |
| - | William E. Todd (Acting) | January 20, 2017 | June 12, 2017 | Donald Trump |
| - | Alice G. Wells (Acting) | June 26, 2017 | June 20, 2020 | |
| - | Dean R. Thompson (Acting) | January 20, 2021 | September 15, 2021 | Joe Biden |
| 7 | Donald Lu | September 15, 2021 | present |