Aspoxicillin Explained

Tradename:	Doyle
Synonyms:	TA-058
Cas Number:	63358-49-6
Pubchem:	71961
Unii:	0745KNO26J
Drugbank:	DB13816
Iupac Name:	(2S,5R,6R)-6-(2R)-2-(2R)-2-Amino-4-(methylamino)-4-oxobutanoylamino]-2-(4-hydroxyphenyl)acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
C:	21
H:	27
N:	5
O:	7
S:	1

Aspoxicillin (trade name Doyle^[1]) is an antibiotic drug of the beta-lactam class.^[2] It is an injectable form of penicillin that is highly active against Gram-positive and Gram-negative bacteria, including Bacillus fragilis,^[3] which is resistant to other beta-lactam antibiotics.^[4] It is approved for use in Japan.^[1]

Notes and References

1. Web site: Aspoxicillin . IUPHAR/BPS Guide to Pharmacology .
2. Matsumoto K . [Review: New antimicrobial agent series XXII: Aspoxicillin] . The Japanese Journal of Antibiotics . 40 . 7 . 1221–1242 . July 1987 . 3316732 .
3. Web site: Aspoxicillin . Inxight Drugs . National Center for Advancing Translational Sciences .
4. Edwards R . Resistance to beta-lactam antibiotics in Bacteroides spp . Journal of Medical Microbiology . 46 . 12 . 979–986 . December 1997 . 9402919 . 10.1099/00222615-46-12-979 .