AsponA antisense RNA explained
AsponA antisense RNA |
Rfam: | RF02812 |
Tax Domain: | Bacteria |
So: | , |
AsponA is a small asRNA transcribed antisense to the penicillin-binding protein 1A gene called ponA. It was identified by RNAseq and the expression was validated by 5' and 3' RACE experiments in Pseudomanas aeruginosa. AsponA expression was up or down regulated under different antibiotic stress. Owing to its location it may be able to prevent the transcription or translation of the opposite gene.[1] Study by Wurtzel et al. and Ferrara et al. also detected its expression.[2] [3]
See also
Notes and References
- Gómez-Lozano M, Marvig RL, Tulstrup MV, Molin S . Expression of antisense small RNAs in response to stress in Pseudomonas aeruginosa . BMC Genomics . 15 . 783 . September 2014 . 1 . 25213728 . 4180829 . 10.1186/1471-2164-15-783 . free .
- Wurtzel O, Yoder-Himes DR, Han K, Dandekar AA, Edelheit S, Greenberg EP, Sorek R, Lory S . The single-nucleotide resolution transcriptome of Pseudomonas aeruginosa grown in body temperature . PLOS Pathogens . 8 . 9 . e1002945 . September 2012 . 23028334 . 3460626 . 10.1371/journal.ppat.1002945 . free .
- Ferrara S, Brugnoli M, De Bonis A, Righetti F, Delvillani F, Dehò G, Horner D, Briani F, Bertoni G . Comparative profiling of Pseudomonas aeruginosa strains reveals differential expression of novel unique and conserved small RNAs . PLOS ONE . 7 . 5 . e36553 . 2012 . 22590564 . 3349714 . 10.1371/journal.pone.0036553 . 2012PLoSO...736553F . free .