Aspergillopepsin I Explained

Aspergillopepsin I
Ec Number:3.4.23.18
Cas Number:9025-49-4

Aspergillopepsin I (Aspergillus acid protease, Aspergillus acid proteinase, Aspergillus aspartic proteinase, Aspergillus awamori acid proteinase, Aspergillus carboxyl proteinase, carboxyl proteinase, Aspergillus kawachii aspartic proteinase, Aspergillus saitoi acid proteinase, pepsin-type aspartic proteinase, Aspergillus niger acid proteinase, sumizyme AP, proctase P, denapsin, denapsin XP 271, proctase) is an enzyme.[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins with broad specificity. Generally favours hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk

This enzyme is found in a variety of Aspergillus species.

See also

Notes and References

  1. Kovaleva GG, Shimanskaya MP, Stepanov VM . The site of diazoacetyl inhibitor attachment to acid proteinase of Aspergillus awamori--an analog of penicillopepsin and pepsin . Biochemical and Biophysical Research Communications . 49 . 4 . 1075–81 . November 1972 . 4565799 . 10.1016/0006-291x(72)90322-1 .
  2. Morihara K, Oka T . Comparative specificity of microbial acid proteinases for synthetic peptides. 3. Relationship with their trypsinogen activating ability . Archives of Biochemistry and Biophysics . 157 . 2 . 561–72 . August 1973 . 4581238 . 10.1016/0003-9861(73)90675-9 .
  3. Davidson R, Gertler A, Hofmann T . Aspergillus oryzae acid proteinase. Purification and properties, and formation of pi-chymotrypsin . The Biochemical Journal . 147 . 1 . 45–53 . April 1975 . 239702 . 1165373 . 10.1042/bj1470045 .
  4. Chang WJ, Horiuchi S, Takahashi K, Yamasaki M, Yamada Y . The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus . Journal of Biochemistry . 80 . 5 . 975–81 . November 1976 . 12156 . 10.1093/oxfordjournals.jbchem.a131385 .
  5. Tanaka N, Takeuchi M, Ichishima E . Purification of an acid proteinase from Aspergillus saitoi and determination of peptide bond specificity . Biochimica et Biophysica Acta (BBA) - Enzymology . 485 . 2 . 406–16 . December 1977 . 21699 . 10.1016/0005-2744(77)90176-0 .
  6. Aspergillopepsin F-A carboxylic proteinase from Aspergillus foetidus . Ostoslavskaya VI, Kotlova EK, Stepanov VM, Rudenskaya GH, Baratova LA, Belyanova LP . Bioorg. Khim. . 1976 . 5 . 595–603 .
  7. Panneerselvam M, Dhar SC . Studies on the peptide bond specificity and the essential groups of an acid proteinase from Aspergillus fumigatus . The Italian Journal of Biochemistry . 30 . 3 . 207–16 . 1981 . 7024192 .
  8. The primary structure of aspergillopepsin A, aspartic proteinase from Aspergillus awamori. IV. Amino acid sequence of the enzyme . Ostoslavskaya VI, Revina LP, Kotlova EK, Surova IA, Levin ED, Timokhima EA, Stepanov VM . Bioorg. Khim. . 1986 . 12 . 1030–1047 .
  9. Purification and characterization of carboxyl proteinase from Aspergillus kawachii . Yagi F, Fan J, Tadera K, Kobayashi A . Agric. Biol. Chem. . 1986 . 50 . 4 . 1029–1033 . 10.1271/bbb1961.50.1029. free .
  10. Comparative study on the specificities of several fungal aspartic and acidic proteinases towards the tetradecapeptide of a renin substrate . Majima E, Oda K, Murao S, Ichishima E . Agric. Biol. Chem. . 1988 . 52 . 3 . 787–793 . 10.1271/bbb1961.52.787. free .

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