The Asian Television Award for Best Actress in a Leading Role is awarded annually by the Asian Television Awards.
| Year | Winner and nominees | English title | Original title |
|---|---|---|---|
| 15th (2010) |  Rebecca Lim | The Pupil | |
| Yang Kuei-mei | The Grass Green Sky | 芳草碧連天 | |
| Pan Li-li | The Addict | 逆子 | |
| Jian Man-shu | Year of the Rain | 那年，雨不停國 | |
| Quan Yi Fong | The Illusionist | 魔幻视界 | |
| Jeanette Aw | Together | 当我们同在一起 | |
| Michelle Chia | Polo Boys | ||
| Janice Koh | The Pupil | ||
| 16th (2011) |  Charmaine Sheh | Can't Buy Me Love | 公主嫁到 |
| Lee Shu-chen | Fairy Suzhen | 仙女不下凡 | |
| Yu Tzu-yu | A Teacher’s Heart | 我愛美金 | |
 Zarynn Min | Gila | ||
| Erra Fazira | Sanggul Beracun | ||
 Miriama Smith | Stolen | ||
| 17th (2012) | Rui En | Unriddle 2 | 最火搭档2 |
| Debbie Goh | The Descendant | 香火 | |
| Yeo Yann Yann | The Descendant | 香火 | |
 Sharlene San Pedro | Maalaala Mo Kaya (Episode: "T-shirt") | ||
| Ann Kok | Show Hand | 注定 | |
| Joanne Peh | A Song to Remember | 星洲之夜 | |
| 18th (2013) | Jade Chou | Falling | 含苞欲墜的每一天 |
| Lorna Tolentino | Pahiram ng Sandali | ||
| Marian Rivera | Temptation of Wife | ||
| Kate Tsui | Highs and Lows | 雷霆掃毒 | |
| Debbie Goh | Mining Magnate | 半边天 | |
| Fang Wen-lin | Go, Hula! | 呼拉姊妹花 | |
| 19th (2014) | Puteri Balqis Azizi | Balqis | |
| Kristal Tin | Brother's Keeper | 巨輪 | |
| Tien Hsin | A Good Wife | 親愛的，我愛上別人了 | |
| Ko Shu-chin | What Time Will You Be Home? | 幾點回家 | |
 Joan Chen | Serangoon Road | ||
| Rui En | Sudden | 骤变 | |
| 20th (2015) | Zhou Xun | Red Sorghum | 紅高粱 |
| Kristal Tin | Black Heart White Soul | 忠奸人 | |
| Ruby Lin | The Way We Were | 16個夏天 | |
| Fang Wen-lin | The Last Waltz | 人生圓舞曲 | |
| Hong Qi-yang | Messages Seen | 已讀不回 | |
| Zhao Wei | Tiger Mom | 虎妈猫爸 | |
| Felicia Chin | Love Is Love: Sunshine | ||
| Suhaillah Salam | Dua Wajah | ||
| 21st (2016) | Cheryl Yang | A Touch of Green | 一把青 |
| Mei Fang | Laugh for 24 Hours | 藥笑24小時 | |
 Fonthip Watcharatrakul | The Sisters | เพื่อน แพง | |
| Ko Chia-yen | La Grande Chaumiere Violette | 紫色大稻埕 | |
| Kristal Tin | Ghost of Relativity | 鬼同你OT | |
| Jojo Goh | The Love Machine | ||
| Farhana M Noor | Bunga Tanjong | ||
| 22nd (2017) | Kara Hui | Affairs of the Heart | |
| Louisa Chong | Beautiful World – Crow | ||
 Ryoko Shinohara | Desperate for Love | ||
| Chantel Liu | The King of Drama | ||
| Ko Chia-yen | Welcome to the Happy Days | ||
| Felicia Chin | 2589 Days Apart | ||
| Zoe Tay | You Can Be An Angel 2 | ||
| 23rd (2018) | Kim Nam-joo | Misty | 미스티 |
| Son Ye-jin | Something in the Rain | ||
| Ali Lee | My Ages Apart | ||
| Herb Hsu | The Alternatives | ||
| Joanne Tseng | Attention, Love! | ||
| Maylada Susri | The Swan and The Dragons | หงส์เหนือมังกร | |
| Sonija Kwok | Below the Lion Rock – Secret | ||
| Maja Salvador | Wildflower | ||
| Yang Chin | Age of Rebellion | ||