Asboe-Hansen sign explained

The Asboe-Hansen sign (also known as "indirect Nikolsky sign'" or "Nikolsky II sign"[1]) refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it.[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions.[4]

This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.[5]

It is considered an indirect diagnostic tool in toxic epidermal necrolysis (TEN).

See also

Notes and References

  1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 1-4160-2999-0 .
  2. James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 16. .
  3. Book: Jonkman . Marcel F. . Horváth . Barbara . Horváth . Barbara . Autoimmune Bullous Diseases . 2022 . Springer . Switzerland . 978-3-030-91557-5 . 13 . 2nd . https://books.google.com/books?id=OiFaEAAAQBAJ&pg=PA13 . en . 2. Dermatological examination of bullous diseases .
  4. Book: James . William D. . Elston . Dirk . Treat . James R. . Rosenbach . Misha A. . Neuhaus . Isaac . Andrews' Diseases of the Skin: Clinical Dermatology . 2020 . Elsevier . Edinburgh . 978-0-323-54753-6 . 13 . 13th . https://books.google.com/books?id=UEaEDwAAQBAJ&pg=PA13 . en . 2. Cutaneous signs and diagnosis .
  5. Freiman . Anatoli . Kalia . Sunil . O'Brien . Elizabeth A. . Dermatologic Signs . Journal of Cutaneous Medicine and Surgery . July 2006 . 10 . 4 . 175–182 . 10.2310/7750.2006.00042.

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