Arylmalonate decarboxylase explained

arylmalonate decarboxylase
Ec Number:	4.1.1.76
Cas Number:	144713-36-0
Go Code:	0047436

The enzyme arylmalonate decarboxylase catalyzes the chemical reaction

2-aryl-2-methylmalonate

\rightleftharpoons 2-arylpropanoate + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropanoate-forming). Other names in common use include AMDASE, 2-aryl-2-methylmalonate carboxy-lyase, and 2-aryl-2-methylmalonate carboxy-lyase (2-arylpropionate-forming).

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Miyamoto K, Ohta H . 1992 . Cloning and heterologous expression of a novel arylmalonate decarboxylase gene from Alcaligenes bronchisepticus KU 1201 . Appl. Microbiol. Biotechnol. . 38 . 234 - 8 . 1369144 . 2 . 10.1007/bf00174474. 11058932 .