Arul Chinnaiyan Explained

Arul Chinnaiyan
Workplaces:	University of Michigan Medical School, Howard Hughes Medical Institute
Alma Mater:	University of Michigan Medical School
Known For:	Cancer Research

Arul M. Chinnaiyan is a Hicks Endowed Professor of Pathology and professor of pathology and urology at the University of Michigan Medical School.^[1] He is also a Howard Hughes medical Investigator (HHMI) at the Howard Hughes Medical Institute.^[2] Arul Chinnaiyan received both PhD and MD degrees at the University of Michigan Medical School in 1999. He is a cancer researcher and the recipient of the 28th annual American Association for Cancer Research Award for Outstanding Achievement in Cancer Research at the annual meeting of the AACR in April 2008 in San Diego.^[3] He was also the leader of a group of scientists who received the inaugural 2007 American Association for Cancer Research "Team Science" Award for their discovery of gene fusions in prostate cancer.^[4]

Arul Chinnaiyan received a number of other awards and prizes, including the Burroughs Wellcome Fund Clinical Scientist Award in Translational Research and of the Ramzi Cotran Young Investigator Award from the United States and Canadian Academy of Pathology. He is an elected member of the American Society for Clinical Investigation.^[5]

He is a member of the editorial board for Oncogene.^[6]

Research and discovery

The focus of his research is molecular profiling of cancer to discover novel diagnostic markers and therapeutic targets. It is generally believed that blood cancers are caused by chromosome translocation such as Bcr-Abl in chronic myelogenous leukaemia (CML), whereas solid tumors are caused by mutations in growth or tumour suppressor genes. In research which challenges the current dogma, Arul has discovered chromosome translocation in solid prostate tumours. Arul has discovered that this translocation occurs between a male hormone related gene TMPRSS2 and transcription factors of the Erythroblast transformation specific (ETS) family.^[7]

Publications

Partial list:

• 20056654 . 10.1093/nar/gkp1180 . 38 . On the detection and refinement of transcription factor binding sites using ChIP-Seq data . 2853110 . April 2010 . Nucleic Acids Res. . 2154–67 . Hu . M . Yu . J . Taylor . JM . Chinnaiyan . AM . Qin . ZS. 7 .
• 18596922 . 10.1172/JCI34780 . 118 . KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis . 2441856 . August 2008 . J. Clin. Invest. . 2711–21 . Narla . G . DiFeo . A . Fernandez . Y . 8 . etal.
• 20005836 . 10.1016/j.molcel.2009.11.019 . 36 . A FIRE-y PAGE in the computational analysis of cancer profiles . December 2009 . Mol. Cell . 732–3 . Prensner . JR . Chinnaiyan . AM. 5 . free .
• 19955085 . 10.1074/mcp.M900159-MCP200 . 9 . Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer . 2830841 . February 2010 . Mol. Cell. Proteomics . 298–312 . Khan . AP . Poisson . LM . Bhat . VB . 2 . free . etal.
• 17319736 . 10.1371/journal.pcbi.0030012 . 3 . From bytes to bedside: data integration and computational biology for translational cancer research . 1808026 . February 2007 . PLOS Comput. Biol. . e12 . Mathew . JP . Taylor . BS . Bader . GD . 2 . 2007PLSCB...3...12M . etal . free .
• Ateeq . B . Tomlins . SA . Chinnaiyan . AM . Dec 2009 . AGTR1 as a therapeutic target in ER-positive and ERBB2-negative breast cancer cases . Cell Cycle . 8 . 23. 3794–5 . 19934656 . 2940713 . 10.4161/cc.8.23.9976 .
• 19933109 . 10.1126/science.1178124 . 326 . Induced chromosomal proximity and gene fusions in prostate cancer . 2935583 . November 2009 . Science . 1230 . Mani . RS . Tomlins . SA . Callahan . K . 5957 . 2009Sci...326.1230M . etal.
• 19881495 . 10.1038/nbt.1584 . 27 . An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer . 3086882 . November 2009 . Nat. Biotechnol. . 1005–11 . Wang . XS . Prensner . JR . Chen . G . 11 . etal.
• 19763266 . 10.1371/journal.pone.0007075 . 4 . Proteomic interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases . 2740864 . 2009 . PLOS ONE . e7075 . Vellaichamy . A . Sreekumar . A . Strahler . JR . 9 . 2009PLoSO...4.7075V . etal. free .
• Gust . KM . Hofer . MD . Perner . SR . Kim . R . Chinnaiyan . AM . Varambally . S . Moller . P . Rinnab . L . Rubin . MA . Greiner . J . Schmitt . M . Kuefer . R . Ringhoffer . M . Sep 2009 . RHAMM (CD168) is overexpressed at the protein level and may constitute an immunogenic antigen in advanced prostate cancer disease . Neoplasia . 11 . 9. 956–63 . 19724689 . 2735808 . 10.1593/neo.09694 .
• 19679545 . 10.1158/0008-5472.CAN-09-1063 . 69 . Melanoma proliferation and chemoresistance controlled by the DEK oncogene . 2727675 . August 2009 . Cancer Res. . 6405–13 . Khodadoust . MS . Verhaegen . M . Kappes . F . 16 . etal.

Notes and References

1. Web site: University of Michigan Medical School Department of Pathology website . 21 April 2008 . https://web.archive.org/web/20070504231105/http://www.pathology.med.umich.edu/faculty/Chinnaiyan/ . 4 May 2007 . dead .
2. http://www.hhmi.org/news/chinnaiyan_bg.html HHMI: Arul M. Chinnaiyan, M.D., Ph.D
3. http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/outstanding-achievement-award.aspx List of AACR Award for Outstanding Achievement in Cancer Research Winners
4. http://www.aacr.org/home/scientists/scientific-achievement-awards/scientific-award-winners/team-science-award-.aspx AACR Team Science Award Recipients
5. http://www.med.umich.edu/opm/newspage/2007/hhmi.htm 2 UMHS researchers selected as Howard Hughes Medical Institute investigators.
6. Web site: Editorial Board | Oncogene.
7. 17671502 . 10.1038/nature06024 . 448 . Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer . 2007 . Nature . 595–9 . Tomlins . SA . Laxman . B . Dhanasekaran . SM . Helgeson . BE . Cao . X . Morris . DS . Menon . A . Jing . X . Cao . Q . Han . B . Yu . J . Wang . L . Montie . JE . Rubin . MA . Pienta . KJ . Roulston . D . Shah . RB . Varambally . S . Mehra . R . Chinnaiyan . AM. 7153 . 2007Natur.448..595T . 2027.42/62659 . 4361134 . free .