Artesunate/amodiaquine explained

Artesunate/amodiaquine, sold under the trade name Camoquin among others, is a medication used for the treatment of malaria.[1] It is a fixed-dose combination of artesunate and amodiaquine. Specifically it recommended for acute uncomplicated Plasmodium falciparum malaria.[2] It is taken by mouth.[1]

Common side effects include loss of appetite, nausea, abdominal pain, sleepiness, trouble sleeping, and cough. Safety in pregnancy is not clear; however, the medication may be used if others are not possible. It is believed to be safe for use during breastfeeding. Artesunate and amodiaquine are both antimalarial medication; however, work by different mechanisms.[3]

Artesunate/amodiaquine was commercially launched in 2007.[4] It is on the World Health Organization's List of Essential Medicines.[5] Artesunate/amodiaquine is available as a generic medication.[4] As of 2014 it is not commercially available in the United States or United Kingdom.[6] [7]

Medical uses

Early clinical trials showed that a once-a-day dosage was effective.[8] It was subsequently clinically shown to be equally effective as artemether/lumefantrine,[9] although it is likely to be more effective in the field due to its simpler once-a-day dosage compared to artemether/lumefantrine twice-per-day dosage.

Society and culture

Artesunate/amodiaquine was commercially launched in 2007 as an affordable treatment for malaria, devised by DNDi in partnership with Sanofi-Aventis.[4] ASAQ was handed over to the MMV Access and Product Management Team in May 2015.[10]

External links

Notes and References

  1. Oyakhirome S, Pötschke M, Schwarz NG, Dörnemann J, Laengin M, Salazar CO, Lell B, Kun JF, Kremsner PG, Grobusch MP . 6 . Artesunate--amodiaquine combination therapy for falciparum malaria in young Gabonese children . Malaria Journal . 6 . 29 . March 2007 . 17352806 . 1831475 . 10.1186/1475-2875-6-29 . free .
  2. Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . ((World Health Organization)) . Stuart MC, Kouimtzi M, Hill SR . 10665/44053 . World Health Organization . World Health Organization . free . 187 .
  3. Web site: Artesunate Amodiaquine Winthrop. WIPO. 12 December 2016. August 2010. live. https://web.archive.org/web/20161024090154/http://www.wipo.int/export/sites/www/research/en/data/sanofi/marketed_products/Artesunate_and_Amodiquine.pdf. 24 October 2016.
  4. Web site: New, Once-a-Day Fixed-Dose Combination Against Malaria Now Available – DNDi. www.dndi.org. 12 December 2016. 1 March 2007. live. https://web.archive.org/web/20161220123856/http://www.dndi.org/2007/media-centre/press-releases/new-once-a-day-fixed-dose-combination-against-malaria-now-available/. 20 December 2016.
  5. Book: ((World Health Organization)) . World Health Organization model list of essential medicines: 21st list 2019 . 2019 . 10665/325771 . World Health Organization . World Health Organization . Geneva . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . free .
  6. Book: Ainsworth SB . Amodiaquine with artesunate . Neonatal Formulary: Drug Use in Pregnancy and the First Year of Life. 2014. John Wiley & Sons. 9781118819517. 75. https://books.google.com/books?id=EORvBAAAQBAJ&pg=PA75. en. live. https://web.archive.org/web/20161220094547/https://books.google.ca/books?id=EORvBAAAQBAJ&pg=PA75. 2016-12-20.
  7. Book: Rosenthal PJ, Kamya M . Malaria . Goldman L, Schafer AI . Goldman-Cecil Medicine. 2015. Elsevier Health Sciences. 9780323322850. 2112. https://books.google.com/books?id=40Z9CAAAQBAJ&pg=PA1354. en. live. https://web.archive.org/web/20161220094525/https://books.google.ca/books?id=40Z9CAAAQBAJ&pg=PA1354. 2016-12-20.
  8. Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, Randrianasolo L, Ratsimbasoa A, Forlemu D, Moor VA, Traore A, Dicko Y, Dara N, Lameyre V, Diallo M, Djimde A, Same-Ekobo A, Gaye O . 6 . Randomized, multicentre assessment of the efficacy and safety of ASAQ--a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria . Malaria Journal . 8 . 125 . June 2009 . 19505304 . 2698916 . 10.1186/1475-2875-8-125 . free .
  9. Ndiaye JL, Faye B, Gueye A, Tine R, Ndiaye D, Tchania C, Ndiaye I, Barry A, Cissé B, Lameyre V, Gaye O . 6 . Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial . Malaria Journal . 10 . 237 . August 2011 . 21838909 . 3171378 . 10.1186/1475-2875-10-237 . free .
  10. Web site: DNDi passes the ball to MMV Medicines for Malaria Venture. www.mmv.org. 22 May 2015 . 2020-02-13.

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