| Arsen Mek'ok'ishvili | |
| Birth Date: | 12 April 1912 |
| Birth Place: | Georgitsminda, Sagarejo Municipality, Georgia, Russian Empire |
| Death Date: | 9 March 1972 (aged 59) |
| Death Place: | Moscow, Russian SFSR, Soviet Union |
| Sport: | Freestyle wrestling |
| Club: | Dynamo Tbilisi |
| Show-Medals: | yes |
Arsen Mek'ok'ishvili (Georgian: არსენ მეკოკიშვილი; 12 April 1912 – 9 March 1972) was a Georgian heavyweight freestyle wrestler. He won an Olympic gold medal in 1952 and a world title in 1954.
Mek'ok'ishvili took up wrestling following his father, a local champion in chidaoba, and in 1934 won the Georgian chidaoba championship. Later around 1939 he changed to sambo and freestyle wrestling, and won the Soviet titles in sambo in 1940 and 1947–52 and in freestyle wrestling in 1945–46, 1948–53 and 1956. Between 1945 and 1954, he lost only one bout, to Johannes Kotkas. After retiring from competitions Mek'ok'ishvili worked as a wrestling coach in Georgia. He died in Moscow as a result of a car accident.