Arpraziquantel Explained

Class:	Anthelmintic
Atc Prefix:	P02
Atc Suffix:	BA03
Cas Number:	57452-98-9
Pubchem:	445900
Drugbank:	DB11749
Chemspiderid:	393394
Unii:	WF15T5925V
Kegg:	D12741
Chembl:	1235551
Pdb Ligand:	PZQ
Synonyms:	(R)-Praziquantel
C:	19
H:	24
N:	2
O:	2
Smiles:	[H][C@@]12CN(CC(=O)N1CCC1=CC=CC=C21)C(=O)C1CCCCC1
Stdinchi:	1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2/t17-/m0/s1
Stdinchikey:	FSVJFNAIGNNGKK-KRWDZBQOSA-N

Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, a medication which is under investigation for the treatment of schistosomiasis in young children with less side effects than the racemate.

Society and culture

Legal status

In December 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion in accordance with Article 58 of Regulation (EC) No 726/20041 for the medicinal product arpraziquantel, intended for the treatment of schistosomiasis in young children. The applicant for this medicinal product is Merck Europe B.V. It is intended exclusively for markets outside the European Union.^[1]

Names

Arpraziquantel is the International nonproprietary name.^[2]

Further reading

• Zdesenko G, Mutapi F . Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models . PLOS Neglected Tropical Diseases . 14 . 9 . e0008649 . September 2020 . 32976496 . 7518612 . 10.1371/journal.pntd.0008649 . free .

Notes and References

1. Web site: . Arpraziquantel . 14 December 2023 . 20 December 2023 . 20 December 2023 . https://web.archive.org/web/20231220045146/https://www.ema.europa.eu/en/opinion-medicine-use-outside-EU/human/arpraziquantel . live . Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
2. ((World Health Organization)) . 2020 . International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 83 . WHO Drug Information . 34 . 1 . 10665/339768 . free . World Health Organization .