Aron Mosnaim Explained

Aron David Mosnaim
Occupation:Neuroscientist, researcher, and academic
Education:PharmD degree
PhD in Organic Chemistry
Alma Mater:University of Chile
University of Strathclyde
Workplaces:Rosalind Franklin University of Medicine and Science
International Neuropsychiatry Consultants

Aron David Mosnaim is a neuroscientist, researcher, and academic. He is an emeritus professor of Cellular and Molecular Pharmacology and an emeritus adjunct professor of Psychiatry and Behavioral Sciences in the Chicago Medical School at Rosalind Franklin University of Medicine and Science.[1]

Mosnaim is most known for his research covering the areas of basic and clinical neuro- and immunopharmacology of biogenic amines and opioid peptides in neuropsychiatric conditions, including depression, headache pain, as well as movement and posttraumatic stress disorders. He has co-edited four scientific books on Noncatecholic Phenylethylamines (2 volumes),[2] Posttraumatic Stress Disorder,[3] and Tardive Dyskinesia.[4]

Mosnaim has served as a Consultant to the Pan American Health Organization (1982–1985), Member of the United States Pharmacopeia Convention (1990 and 1995), and Director of International Neuropsychiatry Consultants (1987–2020). Additionally, he is a Fellow of The Chemical Society (1977) and a Senior Fellow of the American Institute of Therapeutics (2019).[1]

Early life and education

Mosnaim earned a Doctor of Pharmaceutical Sciences degree from the University of Chile (1964) and joined the Faculty of the university's School of Medicine. He was awarded a PhD degree in Organic Chemistry from Glasgow’s Strathclyde University (1969). After a brief tenure at the University of Chicago, he received a postdoctoral fellowship at Northwestern University (1970).

Career

In 1971, Mosnaim joined the University of Health Sciences/The Chicago Medical School as an assistant professor in the Department of Pharmacology. He was promoted to Associate Professor and Acting Chairman (1974), and to a Full Professorship in 1979. He has been serving as a professor of Cellular and Molecular Pharmacology and adjunct professor of Psychiatry and Behavioral Sciences at The Chicago Medical School/Rosalind Franklin University.[1]

Mosnaim holds an Honorary Full Professorship at the University of Chile College of Pharmaceutical Sciences.

Research

Mosnaim has published over 150 papers in peer-reviewed Journals, more than 20 invited reviews and book chapters, and presented research in more than 200 scientific meetings.

Early in his research career (1967), Mosnaim contributed to elucidate the metabolic pathway of the then widely used toxic insecticide DDT (dichlorodiphenyltrichloroethane), and in a series of publications (1969–1972) helped to understand the mechanism of halogenation by cupric salts of carcinogenic anthracene and pyrene compounds.[5] His laboratory demonstrated the presence of phenylethylamine, commonly viewed as the endogenous amphetamine, in mammalian tissues, and his work elucidated this amine’s in vivo and in vitro brain metabolic pathway.[6] [7] [8] His work, animal models, contributed to establish phenylethylamine brain levels as a biological marker for various neuropsychiatric disorders, and to evaluate its brain changes in response to different classes of psychotropic drugs.[9] [10] Further research identified some of the physiological functions, and described relevant behavior and toxicological effects of phenylethylamine and various structurally related trace amines.[11] [12]

Mosnaim reported plasma levels of the endogenous opioid pentapeptide methionine-enkephalin in various patient populations, and the effect of selected classes of drugs on its degradation kinetics,[13] suggesting that its significant increase in chronic cluster and migraine patients during an acute headache episode could serve as a biological marker for these illnesses.[14] [15] He also clarified reports of the activity of platelet monoamine oxidase and the role of dietary phenylethylamine and tyramine in the etiology of migraine headaches.[16]

Mosnaim contributed to document the association of tardive dyskinesia and drug-induced parkinsonism, and in identifying sub-types, cognitive deficits, and some of the risk factors associated with increased vulnerability to this condition.[17] [18] [19] [20] He participated in studies finding comorbidity of pain, dermatological and allergic conditions, as well as decreased natural killer cell activity, in posttraumatic stress disorder patients.[21] He reported the decrease of this immune function in septic shock and human immunodeficiency virus-1 positive individuals, as well as its significant increase by various substances with widely different chemical structures and biological activities, e.g., enkephalins, α-interferon, interleukin-2, taxol, and lipopolysaccharide.[22] [23] [24]

Bibliography

Selected edited books

Selected articles

Notes and References

  1. Web site: Aron D. Mosnaim, PhD. Rosalind Franklin University.
  2. Book: 3516955 . Noncatecholic phenylethylamines .
  3. Kinzie . J. David . Posttraumatic stress disorder: Etiology, phenomenology and treatment. By M. E. Wolf, and A. D. Mosnaim, editors. Washington, D.C.: American Psychiatric Press, Inc., 1990, 270 pages . Journal of Traumatic Stress . October 1991 . 4 . 4 . 607–608 . 10.1002/jts.2490040416 .
  4. Book: Wolf . Marion E. . Mosnaim . Aron D. . Tardive Dyskinesia: Biological Mechanisms and Clinical Aspects . 1988 . American Psychiatric Press . 978-0-88048-176-2 . 17953812 .
  5. Mosnaim . A.D. . Wolf . M.E. . Saavedra . I. . Amaro . A.M. . Cordano . G. . Nonhebel . D.C. . Reaction of cupric(ii) halides with organic compounds-VIII pyrene and some 3-substituted pyrenes . Tetrahedron Letters . January 1973 . 14 . 17 . 1491–1494 . 10.1016/S0040-4039(01)95980-5 .
  6. Mosnaim . AD . Inwang . EE . Sugerman . JH . DeMartini . WJ . Sabelli . HC . Ultraviolet spectrophotometric determination of 2-phenylethylamine in biological samples and its possible correlation with depression . Biological Psychiatry . June 1973 . 6 . 3 . 235–57 . 4732254 .
  7. Inwang . E. E. . Mosnaim . A. D. . Sabelli . H. C. . Isolation and characterization of phenylethylamine and phenylethanolamine from human brain . Journal of Neurochemistry . May 1973 . 20 . 5 . 1469–1473 . 10.1111/j.1471-4159.1973.tb00259.x . 4716838 . 8349615 .
  8. Book: Mosnaim . Aron D. . Wolf . Marion E. . Noncatecholic Phenylethylamines . 1978 . M. Dekker . 978-0-8247-6616-0 .
  9. Wolf . Marion E. . Mosnaim . A.D. . Phenylethylamine in neuropsychiatric disorders . General Pharmacology: The Vascular System . January 1983 . 14 . 4 . 385–390 . 10.1016/0306-3623(83)90020-4 . 6352395 .
  10. Sabelli . H. C. . Vazquez . A. J. . Mosnaim . A. D. . Madrid-Pedemonte . L. . 2-Phenylethylamine as a possible mediator for Δ9-tetrahydrocannabinol-induced stimulation . Nature . March 1974 . 248 . 5444 . 144–145 . 10.1038/248144a0 . 4274244 . 1974Natur.248..144S . 4168572 .
  11. Mosnaim . Aron D. . Callaghan . Owen H. . Hudzik . Thomas . Wolf . Marion E. . Rat Brain-Uptake Index for Phenylethylamine and Various Monomethylated Derivatives . Neurochemical Research . April 2013 . 38 . 4 . 842–846 . 10.1007/s11064-013-0988-1 . 23389662 . 254860661 .
  12. Mosnaim . Aron D. . Wolf . Marion E. . III. O’Donnell . James J. . Hudzik . Thomas . β-Phenylethylamine and various monomethylated and para-halogenated analogs. Acute toxicity studies in mice . Drug and Chemical Toxicology . 3 July 2020 . 43 . 4 . 369–372 . 10.1080/01480545.2018.1551899 . 30614291 . 58557529 .
  13. Mosnaim . Aron D. . Puente . Javier . Saavedra . Rolando . Diamond . Seymour . Wolf . Marion E. . In vitro Human Plasma Leucine5-Enkephalin Degradation Is Inhibited by a Select Number of Drugs with the Phenothiazine Molecule in Their Chemical Structure . Pharmacology . 2003 . 67 . 1 . 6–13 . 10.1159/000066781 . 12444298 . 22740728 .
  14. Mosnaim . Aron D. . Wolf . Marion E. . Chevesich . Jorge . Callaghan . Owen H. . Diamond . Seymour . Plasma Methionine Enkephalin Levels — A Biological Marker for Migraine? . Headache: The Journal of Head and Face Pain . July 1985 . 25 . 5 . 259–267 . 10.1111/j.1526-4610.1985.hed2505259.x . 4030316 . 35728043 .
  15. Mosnaim . Aron D. . Diamond . Seymour . Freitag . Frederick . Chevesich . Jorge . Wolf . Marion E. . Solomon . Glen . Plasma and Platelet Methionine-Enkephalin Levels in Chronic Cluster Patients During an Acute Headache Episode . Headache: The Journal of Head and Face Pain . June 1987 . 27 . 6 . 325–328 . 10.1111/j.1526-4610.1987.hed2706325.x . 3654188 . 29924147 .
  16. Mosnaim . A.D. . Freitag . F. . Karoum . F. . Wolf . M.E. . Diamond . S. . Salas . M.A. . Migraine and the contents of tyramine and phenylethylamine in food . Biological Psychiatry . April 1996 . 39 . 7 . 595 . 10.1016/0006-3223(96)84270-3 . 54244086 .
  17. Wolf . ME . Chevesich . J . Lehrer . E . Mosnaim . AD . The clinical association of tardive dyskinesia and drug-induced parkinsonism . Biological Psychiatry . October 1983 . 18 . 10 . 1181–8 . 6140032 .
  18. Wolf . Marion E. . Mosnaim . Aron D. . Identifying Subtypes of Tardive Dyskinesia . Psychiatric Services . August 1984 . 35 . 8 . 828–830 . 10.1176/ps.35.8.828 . 6479919 .
  19. Wolf . Marion E. . Ryan . Joseph J. . Mosnaim . Aron D. . Cognitive functions in tardive dyskinesia . Psychological Medicine . August 1983 . 13 . 3 . 671–674 . 10.1017/S0033291700048108 . 6137851 . 26957713 .
  20. Wolf . ME . DeWolfe . AS . Ryan . JJ . Lips . O . Mosnaim . AD . Vulnerability to tardive dyskinesia . The Journal of Clinical Psychiatry . September 1985 . 46 . 9 . 367–8 . 2863257 .
  21. . Wolf . M. E . Alavi . A. . Mosnaim . A. D. . Pain, dermatological and allergic conditions in post traumatic stress disorder . Pain, Dermatological and Allergic Conditions in Post Traumatic Stress Disorder . 1988 . 13 . 3 . 237–240 .
  22. Maturana . Patricio . Puente . Javier . Miranda . Dante . Sepulveda . Cecilia . Wolf . Marion E. . Mosnaim . Aron D. . Natural killer cell activity in patients with septic shock . Journal of Critical Care . March 1991 . 6 . 1 . 42–45 . 10.1016/0883-9441(91)90032-O .
  23. Sepúlveda . Cecilia . Puente . Javier . Weinstein . Caroline . Wolf . Marion E. . Mosnaim . Aron D. . Enhancement of natural killer cell activity in HIV-1-infected subjects by a mixture of the calcium ionophore A23187 and the phorbol ester TPA: lack of response to a similar challenge with interleukin-2 or α-interferon . American Journal of Therapeutics . November 1997 . 4 . 11 . 413–422 . 10.1097/00045391-199711000-00013 . 10423640 . 42963577 .
  24. Puente . J . Carvajal . T . Parra . S . Miranda . D . Sepulveda . C . Wolf . ME . Mosnaim . AD . In vitro studies of natural killer cell activity in septic shock patients. Response to a challenge with alpha-interferon and interleukin-2 . International Journal of Clinical Pharmacology, Therapy, and Toxicology . June 1993 . 31 . 6 . 271–275 . 8335423 .

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