Arogenate dehydrogenase (NADP+) explained

arogenate dehydrogenase (NADP+)
Ec Number:	1.3.1.78
Cas Number:	64295-75-6
Go Code:	0033730

In enzymology, an arogenate dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

L-arogenate + NADP⁺

\rightleftharpoons L-tyrosine + NADPH + CO₂

Thus, the two substrates of this enzyme are L-arogenate and NADP⁺, whereas its 3 products are L-tyrosine, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NADP+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), pretyrosine dehydrogenase (ambiguous), TyrAAT1, TyrAAT2, and TyrAa.

References

• Byng G, Whitaker R, Flick C, Jensen RA . 1981 . Enzymology of L-tyrosine biosynthesis in corn (Zea mays) . . 20 . 1289 - 1292 . 10.1016/0031-9422(81)80023-4 . 6 .
• Gaines CG, Byng GS, Whitaker RJ, Jensen RA . 1982 . L-Tyrosine regulation and biosynthesis via arogenate dehydrogenase in suspension-cultured cells of Nicotiana silvestris Speg. et Comes . Planta . 156 . 233 - 240 . 10.1007/BF00393730 . 3 . 24272471. 20673627 .
• Ishikawa T, Hirayama J, Kobayashi Y, Todo T . 2002 . Zebrafish CRY represses transcription mediated by CLOCK-BMAL heterodimer without inhibiting its binding to DNA . Genes Cells . 7 . 1073 - 86 . 12354100 . 10.1046/j.1365-2443.2002.00579.x . 10 . free .
• Bonner CA, Jensen RA, Gander JE, Keyhani NO . 2004 . A core catalytic domain of the TyrA protein family: arogenate dehydrogenase from Synechocystis . Biochem. J. . 382 . 279 - 91 . 15171683 . 10.1042/BJ20031809 . Pt 1 . 1133941 .