Arnold Martin Katz Explained

Arnold Martin Katz (July 30, 1932 – January 25, 2016) was an American medical doctor, professor of cardiology, medical researcher, and author of medical textbooks and research articles.

Career

Arnold Katz was born in Chicago, Illinois. His mother was a piano teacher. His father, Louis N. Katz M.D. was a cardiologist, winner of the Lasker Award and president of the American Physiological Society and American Heart Association. Katz attended the University of Chicago and earned a Bachelor of Arts in 1952.He graduated as a medical doctor from Harvard Medical School in 1956, and did his medical internship at the Massachusetts General Hospital, where he also serveded as medical assistant resident in 1959. He spent 1957-1958 studying protein chemistry in the Laboratory of Christian B. Anfinsen at the National Institutes of Health in Bethesda.^[1] Katz later worked in medical research at the University of California at Los Angeles and the Columbia University in New York, becoming an established investigator of the American Heart Association. In 1969 Katz became the first Philip J. and Harriet L. Goodhart Professor of Medicine (Cardiology) at the Mount Sinai School of Medicine. In 1977 he moved to the University of Connecticut School of Medicine to become the first chief of cardiology. Since his retirement in 1998 he has been acting as visiting professor of Medicine and Physiology at Dartmouth Medical School. In 2008 he was also appointed Visiting Professor of Medicine at Harvard Medical School.

Katz published over 400 articles and edited or co-edited more than 15 books. His single-authored text Physiology of the Heart is now in its 5th edition. Katz is the recipient of various awards including the 1975 Humboldt Prize, the Research Achievement Award of the American Heart Association, the Peter Harris Distinguished Scientist Award of the International Society for Heart Research, the Lifetime Achievement Award of the Heart Failure Society of America,^[2] and the Medal of Merit of the International Academy of Cardiovascular Sciences.^[3] The American Heart Association renamed its young investigator award for basic research the Louis N. and Arnold M. Katz Prize in his honour.^[4] Among his many contributions, Katz was the first to describe the protein Phospholamban.

Katz passed away at his home in Norwich, Vermont on January 25, 2016. He is survived by his wife of 56 years, Phyllis B. Katz, and their 4 children and 8 grandchildren.^[5]

Publications (incomplete list)

• Physiology of the Heart^[6]
• Heart Failure: Pathophysiology, Molecular Biology, Clinical Management^[7]
• Effects of acetate and other short-chain fatty acids on yeast metabolism^[8]
• Regulation of myocardial contractility 1958-1983: an odyssey^[9]
• Regulation of coronary flow.^[10]
• Registration of left ventricular volume curves in the dog with the systemic circulation intact.^[11]
• Peptide separation by two-dimensional chromatography and electrophoresis.^[12]
• Katz AM, Chernoff AI . 1959 . Structural similarities between hemoglobins A and F. . Science . 130 . 3388. 1574–1576 . 10.1126/science.130.3388.1574. 14404785 . 1959Sci...130.1574K . 40013191 .
• Influence of tropomyosin upon the reactions of actomyosin at low ionic strength.^[13]
• Purification and properties of a tropomyosin-containing protein fraction that sensitizes reconstituted actomyosin to calcium-binding agents.^[14]
• Control of the activity of highly purified cardiac actomyosin by Ca++, Na+ and K+.^[15]
• Katz AM, Repke DI . 1967 . Quantitative aspects of dog cardiac microsomal calcium binding and calcium uptake . Circulation Research . 21 . 2. 153–162 . 10.1161/01.res.21.2.153. 4952707 . free .
• Kirchberger MA, Tada M, Repke DI, Katz AM . 1972 . Cyclic adenosine 3', 5'-monophosphate-dependent protein kinase stimulation of calcium uptake by canine cardiac microsomes . J Mol Cell Cardiol . 4 . 6 . 673–680 . 10.1016/0022-2828(72)90120-4. 4347149 .
• Tada M, Kirchberger MA, Katz AM . 1975 . Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3', 5'-monophosphate-dependent protein kinase . J Biol Chem . 250 . 7. 2640–2647 . 10.1016/S0021-9258(19)41650-5 . 235523 . free .
• Katz AM, Repke DI, Dunnett J, Hasselbach W . 1977 . Dependence of calcium permeability of sarcoplasmic reticulum vesicles on external and internal calcium ion concentrations . J Biol Chem . 252 . 6 . 1950–1956 . 10.1016/S0021-9258(18)71849-8 . 403187 . free .
• Hicks MJ, Shigekawa M, Katz AM . 1979 . Mechanism by which cyclic adenosine 3', 5'-monophosphate-dependent protein kinase stimulates calcium transport in cardiac sarcoplasmic reticulum . Circulation Research . 44 . 3. 384–391 . 10.1161/01.res.44.3.384. 216505 . free .
• Shigekawa M, Dougherty JP, Katz AM . 1978 . Reaction mechanism of Ca2+-dependent ATP hydrolysis by skeletal muscle sarcoplasmic reticulum in the absence of added alkali metal salts. I. Characterization of steady state ATP hydrolysis and comparison with that in the presence of KCl . J Biol Chem . 253 . 5 . 1442–1450 . 10.1016/S0021-9258(17)34886-X . 627548 . free .
• Takenaka H, Adler PN, Katz AM . 1982 . Calcium fluxes across the membrane of sarcoplasmic reticulum vesicles . J Biol Chem . 257 . 21. 12649–12656 . 10.1016/S0021-9258(18)33560-9 . 6215402 . free .
• Katz AM, Adler PN, Watras J, Messineo FC, Takenaka H, Louis CF . 1982 . Fatty acid effects on calcium influx and efflux in sarcoplasmic reticulum vesicles from rabbit skeletal muscle . Biochim Biophys Acta . 687 . 1 . 17–26 . 10.1016/0005-2736(82)90165-1. 7074105 .
• Herbette LG, Katz AM, Sturtevant JM . 1983 . Comparisons of the interaction of propranolol and timolol with model and biological membrane systems . Mol Pharmacol . 24 . 2. 259–269 . 6888369 .
• Herbette LG, Trumbore M, Chester DW, Katz AM . 1988 . Possible molecular basis for the pharmacodynamics of three membrane active drugs: propranolol, nimodipine, amiodarone . J Mol Cell Cardiol . 20 . 5. 373–378 . 10.1016/s0022-2828(88)80128-7. 3210248 .
• Katz AM . 1965 . The descending limb of the Starling Curve and the failing heart . Circulation . 32 . 6. 871–875 . 10.1161/01.cir.32.6.871. 5321024 . free .
• Katz AM "Biochemical "defect" in the hypertrophied and failing heart. Deleterious or compensatory" Circulation 1973;1076-1079.
• Katz AM, Hecht HH . 1969 . The early "pump" failure of the ischemic heart . Am J Med . 47 . 4. 497–502 . 10.1016/0002-9343(69)90180-6. 4241836 . free .
• Katz AM, Tada M . 1972 . The "Stone Heart": A challenge to the biochemist . Am J Cardiol . 29 . 4. 578–580 . 10.1016/0002-9149(72)90455-9. 5016841 .
• Katz AM, Reuter H . 1979 . Cellular calcium and cardiac cell death . Am J Cardiol . 44 . 1. 188–190 . 10.1016/0002-9149(79)90270-4. 36745 .
• Katz AM . 1978 . A new inotropic drug: Its promise and a caution . N Engl J Med . 299 . 25. 1409–1410 . 10.1056/nejm197812212992508 . 714118.
• Katz AM. "Potential deleterious effects of inotropic agents in the therapy of heart failure. Circulation 1986;73(Suppl III):184-190.
• Katz AM . 1988 . Molecular biology in cardiology, a paradigmatic shift . J Mol Cell Cardiol . 20 . 4. 355–366 . 10.1016/s0022-2828(88)80069-5. 3050135 .
• Katz AM . 1990 . Cardiomyopathy of overload. A major determinant of prognosis in congestive heart failure . 10.1056/nejm199001113220206 . N Engl J Med . 322 . 2 . 100–110 . 2403651 .
• Katz AM . 1990 . Angiotensin II: Hemodynamic regulator or growth factor? . J Mol Cell Cardiol . 22 . 7. 739–747 . 10.1016/0022-2828(90)90086-H . 2231742 .
• Katz AM, Katz PB . 1989 . Homogeneity out of heterogeneity . Circulation . 79 . 3. 712–717 . 10.1161/01.cir.79.3.712. 2917394 . free .
• Katz AM . 1992 . T Wave "Memory": Possible causal relationship to stress-induced changes in cardiac ion channels? . J Cardiovasc Electrophysiol . 3 . 2. 150–159 . 10.1111/j.1540-8167.1992.tb01104.x. 145397770 .
• Katz AM . 1992 . Heart Failure in 2001: A prophesy . 10.1016/0002-9149(92)91370-j . Am J Cardiol . 70 . 10. 126C–131C . 1414889 .
• Katz AM . 2001 . Heart Failure in 2001. A prophesy revisited . Am J Cardiol . 87 . 12. 1383–1386 . 10.1016/s0002-9149(01)01557-0. 11397358 .
• Katz AM . 2008 . The "modern" view of heart failure: How did we get here? . Circ Heart Fail . 1 . 1. 63–71 . 10.1161/circheartfailure.108.772756 . 19808272. free .
• Katz AM . 2008 . The "gap" between bench and bedside: Widening or narrowing . J Cardiac Failure . 14 . 2. 91–94 . 10.1016/j.cardfail.2007.10.012. 18325453 .

Notes and References

1. Web site: Arnold M. Katz. American Physiological Society. 9 March 2014. https://web.archive.org/web/20140724072120/http://www.the-aps.org/mm/Membership/Living-History/Katz. 24 July 2014. dead.
2. Web site: Arnold M. Katz Receives 2007 HFSA Lifetime Achievement Award . Heart Failure Society of America . 10 March 2014 . dead . https://web.archive.org/web/20101203074200/http://hfsa.org/pdf/hfsa_news25.pdf . 3 December 2010 .
3. Web site: Medal of Merit Recipients. International Academy of Cardiovascular Science. 10 March 2014.
4. Web site: Louis N. and Arnold M. Katz Basic Research Prize . American Heart Association . 10 March 2014 . dead . https://web.archive.org/web/20140310124550/http://my.americanheart.org/professional/Councils/AwardsandLectures/EarlyCareer/Louis-N-and-Arnold-M-Katz-Basic-Research-Prize_UCM_322570_Article.jsp . 10 March 2014 .
5. Web site: Arnold M. Katz . Hartford Courant . 14 January 2021.
6. Book: Katz, Arnold M.. Physiology of the heart. 2005. Lippincott Williams & Wilkins. Philadelphia, Pa.. 9780781755016. 4th.
7. Book: Konstam, Arnold M. Katz, Marvin A.. Heart failure : pathophysiology, molecular biology, and clinical management. 2009. Wolters Kluwer Health/Lippincott Williams & Wilkins. Philadelphia. 978-0781769464. 2nd.
8. SAMSON. FE. KATZ, AM . HARRIS, DL . Effects of acetate and other short-chain fatty acids on yeast metabolism.. Archives of Biochemistry and Biophysics. Feb 1955. 54. 2. 406–23. 14350790. 10.1016/0003-9861(55)90054-0.
9. Katz. AM. Regulation of myocardial contractility 1958-1983: an odyssey.. Journal of the American College of Cardiology. Jan 1983. 1. 1. 42–51. 6131087. 10.1016/s0735-1097(83)80009-6. free.
10. KATZ. AM. KATZ, LN . WILLIAMS, FL . Regulation of coronary flow.. The American Journal of Physiology. Feb 1955. 180. 2. 392–402. 14361747. 10.1152/ajplegacy.1955.180.2.392.
11. KATZ. A. M.. KATZ, L. N.. WILLIAMS, F. L.. Registration of Left Ventricular Volume Curves in the Dog with the Systemic Circulation Intact. Circulation Research. 1 November 1955. 3. 6. 588–593. 10.1161/01.RES.3.6.588. 13270373. free.
12. KATZ. AM. DREYER, WJ . ANFINSEN, CB . Peptide separation by two-dimensional chromatography and electrophoresis.. The Journal of Biological Chemistry. Nov 1959. 234. 11 . 2897–900. 10.1016/S0021-9258(18)69690-5 . 14404782 . free .
13. KATZ. AM. Influence of Tropomyosin Upon the Reactions of Actomyosin at Low Ionic Strength. The Journal of Biological Chemistry. Oct 1964. 239. 10 . 3304–11. 10.1016/S0021-9258(18)97720-3 . 14245378 . free .
14. Katz. AM. Purification and properties of a tropomyosin-containing protein fraction that sensitizes reconstituted actomyosin to calcium-binding agents.. The Journal of Biological Chemistry. Apr 10, 1966. 241. 7. 1522–9. 10.1016/S0021-9258(18)96743-8 . 4223545 . free .
15. Katz. AM. Repke, DI . Cohen, BR . Control of the activity of highly purified cardiac actomyosin by Ca2+, Na+ and K+.. Circulation Research. Dec 1966. 19. 6. 1062–70. 4224636. 10.1161/01.res.19.6.1062. free.