| Arnaldo Orfila Reynal | |
| Birth Date: | July 9, 1897 |
| Birth Place: | La Plata, Argentina |
| Death Date: | January 13, 1998 (aged 100) |
| Death Place: | Mexico City, Mexico |
| Nationality: | Argentina and Mexico |
| Alma Mater: | National University of La Plata |
| Spouse: | Laurette Séjourné |
Arnaldo Orfila Reynal (9 July 1897 – 13 January 1998) was an Argentine-Mexican publisher. Orfila Reynal was director of the Fondo de Cultura Económica (Economic Culture Fund) and its subsidiary in Argentina. In 1965 he founded the publishing house Siglo Veintiuno Editores with the assistance of University of Buenos Aires.