| Arlene Semeco | |
| Fullname: | Arlene Iradie Semeco Arismendi |
| Nationality: |  Venezuela, Bolivarian Republic of |
| Birth Place: | Caracas, Venezuela |
| Weight: | 63kg (139lb) |
| Headercolor: | lightsteelblue |
| Show-Medals: | yes |
| Club: | Coral Springs Swim Club South Florida Aquatic Club Alabama Crimson Tide |
Arlene Iradie Semeco Arismendi (born January 11, 1984) is a female freestyle swimmer from Venezuela, who represented her native country in three consecutive Summer Olympics, starting in 2004. She won two gold medals at the 2007 Pan American Games. She attended the University of Alabama.