| State: | AR |
| Type: | AR |
| Route: | 375 |
| Map Custom: | yes |
| Length Mi1: | 8.09 |
| Length Ref1: | [1] |
| Direction A1: | West |
| Terminus A1: | at Potter Junction |
| Direction B1: | East |
| Terminus B1: | in Mena |
| Length Mi2: | 11.62 |
| Direction A2: | North |
| Terminus A2: | near Mena |
| Direction B2: | South |
| Terminus B2: | in the Ouachita National Forest |
| Counties: | Polk |
| Previous Type: | AR |
| Previous Route: | 374 |
| Next Type: | AR |
| Next Route: | 376 |
Highway 375 (AR 375, Ark. 375, and Hwy. 375) is a designation for one east-west and one north–south state highway in Polk County, Arkansas. A western route of 8.09miles runs east from U.S. Route 59/U.S. Route 71 (US 59/US 71) at Potter Junction to Highway 8 in Mena.[2] A second route of 11.62miles begins at Highway 8 outside of Mena and runs south beyond County Road 630 to Shady, Arkansas, in the Ouachita National Forest.
Highway 375 begins at US 59/US 71 at Potter Junction. The route runs west through farms and wooded areas before turning north to Potter. Highway 375 turns east and follows old US 71 to its end at Highway 8 in Mena.
Highway 375 begins at Highway 8 outside of Mena and runs southeast through Dallas. The route continues southeast to enter the Ouachita National Forest where it becomes a narrow road with almost no shoulder and limited signage. 375 has many sharp turns as it crosses the mountain and is NOT passable by large trucks, ie. 18 wheelers. Highway 375 terminates at County Road 81 (community of Shady). Polk County Road 64 continues East where 375 ends. CR 64 is a partial paved/dirt road that enters the forest and is not passable by large trucks.