Ariadne (drug) explained

Ariadne (also known as 4C-D, 4C-DOM, α-Et-2C-D, BL-3912, or dimoxamine) is a little-known psychoactive drug. It is a homologue of the psychedelics 2C-D and DOM. Ariadne was first synthesized by Alexander Shulgin. In his 1991 book PiHKAL, Shulgin reported testing Ariadne on himself up to a dose of 32 mg, finding that it produced "the alert of a psychedelic, with none of the rest of the package".^[1] Very little published data exists about the human pharmacology of Ariadne apart from Shulgin's limited testing; unpublished human trials reportedly observed some psychoactive effects, but no hallucinations.^{[2] [3]}

Shulgin reported that the drug was tested by Bristol Laboratories as an antidepressant, in an anecdote where he was explaining how human testing is invaluable (compared to animal testing) on drugs that change the state of the mind. He said, "Before they launched into a full multi-clinic study to determine whether it's going to be worth the animal studies or not, every person on the board of directors took it."^[4]

In animal studies, Ariadne was shown to produce stimulus generalization in rats trained to respond to MDMA^[5] or LSD.

See also

• 4C-B
• 4C-T-2
• Phenethylamine
• Psychedelics, dissociatives and deliriants

External links

• ARIADNE Entry at PiHKAL·info

Notes and References

1. Book: Shulgin . Alexander T. . PiHKAL: a chemical love story . Shulgin . Ann . 1991 . Transform Press . 9780963009609 . 1st . Berkeley, CA . 25627628.
2. Winter . J. C. . 1980-05-01 . Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus . Psychopharmacology . en . 68 . 2 . 159–162 . 10.1007/BF00432134 . 6776559 . 12221170 . 1432-2072.
3. Cunningham . Michael J. . Bock . Hailey A. . Serrano . Inis C. . Bechand . Benjamin . Vidyadhara . D. J. . Bonniwell . Emma M. . Lankri . David . Duggan . Priscilla . Nazarova . Antonina L. . Cao . Andrew B. . Calkins . Maggie M. . Khirsariya . Prashant . Hwu . Christopher . Katritch . Vsevolod . Chandra . Sreeganga S. . 2022-12-15 . Pharmacological Mechanism of the Non-hallucinogenic 5-HT2A Agonist Ariadne and Analogs . ACS Chemical Neuroscience . 14 . 1 . 119–135 . 10.1021/acschemneuro.2c00597 . 1948-7193 . 36521179. 10147382 .
4. Book: The Nature of Drugs . Alexander Shulgin . 299–300 . 2021 . 9780999547212 . Transform Press . Berkeley, California.
5. Pharmacol Biochem Behav . 1993 . 46 . 2 . 459–462 . MDMA-like stimulus effects of alpha-ethyltryptamine and the alpha-ethyl homolog of DOM . Glennon RA . 10.1016/0091-3057(93)90379-8 . 7903460 . 54356633 .