Ardem Patapoutian Explained

Ardem Patapoutian
Birth Place:Beirut, Lebanon
Awards:Nobel Prize in Physiology or Medicine (2021)
Education:American University of Beirut
University of California, Los Angeles (BS)
California Institute of Technology (MS, PhD)
Fields:Molecular biology, neuroscience
Workplaces:Scripps Research
Doctoral Advisor:Barbara Wold
Thesis Title:The role of the MyoD family genes during mouse development
Thesis Url:https://resolver.caltech.edu/CaltechTHESIS:10042021-225839792
Thesis Year:1996
Known For:research of PIEZO1, PIEZO2, TRPM8 receptors
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Ardem Patapoutian (born 1967)[1] is a Lebanese-American molecular biologist, neuroscientist, and Nobel Prize laureate of Armenian descent.[2] He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research in La Jolla, California. In 2021, he won the Nobel Prize in Physiology or Medicine jointly with David Julius.

Early life

Ardem Patapoutian (Armenian: Արտեմ Փաթափութեան) was born to a Lebanese Armenian family in Beirut, Lebanon.[3] [4] His father, Sarkis Patapoutian (better known by the pen name), is a poet and an accountant,[5] while his mother, Haiguhi Adjemian, was the principal of an Armenian school in Beirut. He has a brother, Ara, and a sister, Houry.[6] His grandparents settled in Lebanon from Hadjin after surviving the Armenian Genocide.[7] [8] [9]

He is childhood friends with journalist and author Vicken Cheterian.[10] He attended the Demirdjian and Hovagimian Armenian schools in Beirut. He enrolled at the American University of Beirut for a year before emigrating to the United States in 1986.[11] He received a B.S. degree in cell and developmental biology from the University of California, Los Angeles in 1990 and a Ph.D. degree in biology from the California Institute of Technology in 1996 under direction of Barbara Wold.[12] [13]

As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the University of California, San Francisco.[14] In 2000, he became an assistant professor at the Scripps Research Institute. Between 2000 and 2014, he had an additional research position for the Novartis Research Foundation.[15] Since 2014, Patapoutian has been an investigator for the Howard Hughes Medical Institute (HHMI).

Personal life

Patapoutian, a naturalized US citizen, lives in Del Mar, California with his wife Nancy Hong, a venture capitalist, and son, Luca.[16] [17] [18] [19]

Research

Patapoutian's research is into the biological receptors for temperature and touch (nociception). The knowledge is used to develop treatments for a range of diseases, including chronic pain.[20] The discoveries made it possible to understand how heat, cold and mechanical forces trigger nerve impulses.

Patapoutian researches the signal transduction of sensors. Patapoutian and co-workers inactivated genes. In this way, they identified the gene, that made the cells insensitive for touch.[21] The channel for the sense of touch was called PIEZO1 . Through its similarity to PIEZO1, a second gene was discovered and named PIEZO2.[22] This ion channel, the more important of the two mechanoreceptors, is essential for the sense of touch.[23] PIEZO1 and PIEZO2 channels have been shown to regulate additional important physiological processes including blood pressure, respiration and urinary bladder control.

Patapoutian also made significant contributions to the identification of novel ion channels and receptors that are activated by temperature, mechanical forces or increased cell volume.[24] [25] Patapoutian and co-workers were able to show that these ion channels play an outstanding role in the sensation of temperature, in the sensation of touch, in proprioception,[26] in the sensation of pain and in the regulation of vascular tone. More recent work uses functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction).[27] [28] [29] [30]

Awards and honors

Patapoutian has an h-index of 68 according to Google Scholar, and of 63 according to Scopus . He has been a Fellow of the American Association for the Advancement of Science since 2016, a member of the National Academy of Sciences since 2017[31] and of the American Academy of Arts and Sciences since 2020.[32]

In 2017, Patapoutian received the W. Alden Spencer Award,[33] in 2019 the Rosenstiel Award,[34] in 2020 the Kavli Prize for Neuroscience,[35] and the BBVA Foundation Frontiers of Knowledge Award in Biology / Biomedicine.[36]

In 2021, he was awarded the Nobel Prize in Physiology or Medicine jointly with David Julius for their discoveries of receptors for temperature and touch.[37] [38] [39]

In October 2021 President of Lebanon Michel Aoun awarded Patapoutian the Lebanese Order of Merit.[40]

In December 2021, Patapoutian received the American Academy of Achievement’s Golden Plate Award presented by Awards Council member Frances Arnold.[41]

In 2022, Patapoutian was named by Carnegie Corporation of New York as an honoree of the Great Immigrants Award.[42]

Recognition in Armenia

Patapoutian, the first Armenian Nobel laureate, received a hero's welcome when he visited Armenia in June 2022. Prime Minister Nikol Pashinyan awarded him the Order of St. Mesrop Mashtots,[43] while the Armenian National Academy of Sciences elected him an honorary member,[44] and the Yerevan State Medical University awarded him an honorary doctorate.[45] Patapoutian gifted a replica of his Nobel medal to the History Museum of Armenia.[46] [47] HayPost issued a stamp dedicated to him.[48]

Selected publications

PIEZO1 + PIEZO2

PIEZO2

External links

Notes and References

  1. Web site: The Nobel Prize in Physiology or Medicine 2021 . NobelPrize.org . January 10, 2022 . January 11, 2022.
  2. Web site: Ahlander. Johan. Burger. Ludwig. October 4, 2021. Two Americans win Medicine Nobel for work on heat and touch. live. October 5, 2021. Reuters. en. https://web.archive.org/web/20211004095036/https://www.reuters.com/business/healthcare-pharmaceuticals/julius-patapoutian-win-2021-nobel-prize-medicine-2021-10-04/ . October 4, 2021 .
  3. Web site: October 4, 2021. Americans Julius and Patapoutian win 2021 Nobel Prize in Medicine. October 5, 2021. The Indian Express.
  4. Web site: April 30, 2020. Scripps Research neurobiologist Ardem Patapoutian elected to American Academy of Arts and Sciences. live. October 5, 2021. Scripps Research. https://web.archive.org/web/20210310150556/https://www.scripps.edu/news-and-events/press-room/2020/20200430-patapoutian-academy.html . March 10, 2021 .
  5. News: Braidy . Nour . Ardem Patapoutian: The journey of a boy from Beirut who won the Nobel Prize . . October 12, 2021 . https://web.archive.org/web/20211106165130/https://today.lorientlejour.com/article/1277723/ardem-patapoutian-the-journey-of-a-boy-from-beirut-who-won-the-nobel-prize.html . November 6, 2021.
  6. Web site: Նոբելյան մրցանակ է շնորհվել հայազգի գիտնական Արտեմ Փաթափությանին . sci.am . . https://web.archive.org/web/20211028170749/https://www.sci.am/m/newsview.php?id=427&langid=1 . October 28, 2021 . hy . October 6, 2021.
  7. Web site: Patapoutian . Ardem . The Armenian Genocide is still denied and ignored by many but is commemorated by Armenians around the globe on April 24 (107th anniversary this year). Today I am thinking of my ancestors who perished and those who survived and started a new life in Lebanon. . Twitter . https://archive.today/20220507192058/https://twitter.com/ardemp/status/1518110756801110018 . May 7, 2022 . April 24, 2022.
  8. News: 'My family's history is represented here' – Ardem Patapoutian visits Armenian Genocide Memorial . . June 16, 2022 . https://web.archive.org/web/20220625220019/https://armenpress.am/eng/news/1086159 . June 25, 2022.
  9. Web site: ARDEM PATAPOUTIAN WINS NOBEL PRIZE IN MEDICINE . Armenianprelacy.org.
  10. Web site: Mari. Taryan. Արտեմ Փաթափությանի մանկությունը՝ բասկետբոլի եւ պատերազմի արանքում . mediamax.am . https://web.archive.org/web/20211108202019/https://mediamax.am/am/news/science/44846/ . November 8, 2021 . hy . October 5, 2021.
  11. Web site: October 5, 2021. Nobel Prize for AUB alumnus and former student Ardem Patapoutian. October 5, 2021. American University of Beirut.
  12. The Role of the MyoD Family Genes During Mouse Development . 1996 . California Institute of Technology . Ph.D. . Patapoutian . Ardem . . 35966904.
  13. Web site: March 12, 2021. Ardem Patapoutian. live. https://web.archive.org/web/20210624204431/https://kavliprize.org/prizes-and-laureates/laureates/ardem-patapoutian. June 24, 2021. June 23, 2021. www.kavliprize.org.
  14. Web site: October 4, 2021. Scripps Research neuroscientist Ardem Patapoutian receives 2021 Nobel Prize in Physiology. October 5, 2021. Scripps Research.
  15. Web site: Medizin-Nobelpreis für Entschlüsselung des Taststinns . tagesschau.de . October 4, 2021 . de . October 6, 2021.
  16. News: Robbins . Gary . Del Mar's Ardem Patapoutian receives Nobel Prize during special ceremony in Irvine . . . December 9, 2021 . https://web.archive.org/web/20211209172419/https://www.delmartimes.net/news/story/2021-12-09/ardem-patapoutian-nobel-prize . December 9, 2021.
  17. News: Robbins . Gary . San Diego's Ardem Patapoutian experiences the dizzying, fragile joy of winning the Nobel Prize . . November 7, 2021 . https://web.archive.org/web/20211225070850/https://webcache.googleusercontent.com/search?q=cache%3Av9iky-_S-ZYJ%3Ahttps%3A%2F%2Fwww.sandiegouniontribune.com%2Fnews%2Fscience%2Fstory%2F2021-11-07%2Fardem-patapoutian-nobel-life+&cd=12&hl=en&ct=clnk&gl=am . December 25, 2021 . ...Patapoutian and his wife, venture capitalist Nancy Hong....
  18. News: Nobel Prize Laureate Finds Out He Won While in Bed, Check Out Viral Picture Here . . October 5, 2021 . https://web.archive.org/web/20211005082100/https://www.thequint.com/neon/social-buzz/nobel-prize-laureate-receives-honour-while-in-bed-photo-goes-viral#read-more . October 5, 2021.
  19. Web site: New medicine laureate Ardem Patapoutian and his son Luca, watching the #NobelPrize press conference shortly after finding out the happy news . Twitter . . https://archive.today/20211225070551/https://twitter.com/nobelprize/status/1444970585709219840?lang=en . December 25, 2021 . October 4, 2021.
  20. Web site: April 15, 2019. Medizin-Nobelpreis – US-Forscher David Julius und Ardem Patapoutian ausgezeichnet. live. https://web.archive.org/web/20211004145419/https://www.deutschlandfunk.de/medizin-nobelpreis-us-forscher-david-julius-und-ardem.2932.de.html?drn%3Anews_id=1308201. October 4, 2021. October 4, 2021. Deutschlandfunk. de.
  21. Web site: October 4, 2021. Nobel Prize in Medicine Awarded to David Julius and Ardem Patapoutian. October 4, 2021. The New York Times.
  22. Web site: October 4, 2021. The Nobel Prize in Physiology or Medicine 2021. October 4, 2021. NobelPrize.org.
  23. Web site: October 4, 2021. Medizin-Nobelpreis: Wie Nervenzellen Temperaturen und Berührungen erkennen. October 5, 2021. Deutsches Ärzteblatt. de.
  24. Syeda. Ruhma. Qiu. Zhaozhu. Dubin. Adrienne E.. Murthy. Swetha E.. Florendo. Maria N.. Mason. Daniel E.. Mathur. Jayanti. Cahalan. Stuart M.. Peters. Eric C.. Montal. Mauricio. Patapoutian. Ardem. January 28, 2016. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Cell. 164. 3. 499–511. 10.1016/j.cell.2015.12.031. 1097-4172. 4733249. 26824658.
  25. Qiu. Zhaozhu. Dubin. Adrienne E.. Mathur. Jayanti. Tu. Buu. Reddy. Kritika. Miraglia. Loren J.. Reinhardt. Jürgen. Orth. Anthony P.. Patapoutian. Ardem. 2014. SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel. Cell. Elsevier BV. 157. 2. 447–458. 10.1016/j.cell.2014.03.024. 0092-8674. 4023864. 24725410.
  26. Woo. Seung-Hyun. Lukacs. Viktor. de Nooij. Joriene C. Zaytseva. Dasha. Criddle. Connor R. Francisco. Allain. Jessell. Thomas M. Wilkinson. Katherine A. Patapoutian. Ardem. November 9, 2015. Piezo2 is the principal mechanotransduction channel for proprioception. Nature Neuroscience. Springer Science and Business Media LLC. 18. 12. 1756–1762. 10.1038/nn.4162. 1097-6256. 4661126. 26551544.
  27. Web site: Ardem Patapoutian. live. https://web.archive.org/web/20210202113742/https://www.scripps.edu/faculty/patapoutian/. February 2, 2021. October 4, 2021. Scripps Research.
  28. Web site: December 17, 2019. Piezo channels in mechanotransduction: Sensory biology to disease – Ardem Patapoutian. live. https://web.archive.org/web/20211004145413/https://neuroscience.stanford.edu/events/piezo-channels-mechanotransduction-sensory-biology-disease-ardem-patapoutian. October 4, 2021. October 4, 2021. Wu Tsai Neurosciences Institute.
  29. Syeda. Ruhma. Xu. Jie. Dubin. Adrienne E. Coste. Bertrand. Mathur. Jayanti. Huynh. Truc. Matzen. Jason. Lao. Jianmin. Tully. David C. Engels. Ingo H. Petrassi. H Michael. May 22, 2015. Chemical activation of the mechanotransduction channel Piezo1. eLife. eLife Sciences Publications, Ltd. 4. 10.7554/elife.07369. 2050-084X. 4456433. 26001275. Montal. Mauricio. Bandell. Michael. Patapoutian. Ardem. Schumacher. Andrew M . free .
  30. Murthy. Swetha E.. Dubin. Adrienne E.. Patapoutian. Ardem. October 4, 2017. Piezos thrive under pressure: mechanically activated ion channels in health and disease. Nature Reviews Molecular Cell Biology. Springer Science and Business Media LLC. 18. 12. 771–783. 10.1038/nrm.2017.92. 1471-0072. 28974772. 20977908.
  31. Web site: Ardem Patapoutian. live. https://web.archive.org/web/20200603212100/http://www.nasonline.org/member-directory/members/20041844.html. June 3, 2020. January 30, 2021. www.nasonline.org.
  32. Web site: Members Elected in 2020. live. https://web.archive.org/web/20210122223037/https://www.amacad.org/news/members-elected-2020. January 22, 2021. January 30, 2021. American Academy of Arts & Sciences. December 9, 2020 .
  33. News: June 4, 2020. The Thirty-Ninth Annual W. Alden Spencer Award and Lecture. Kavli Institute for Brain Science. live. January 30, 2021. https://web.archive.org/web/20201227080457/https://www.kavli.cuimc.columbia.edu/news/thirty-ninth-annual-w-alden-spencer-award-and-lecture. December 27, 2020.
  34. Web site: Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research. live. https://web.archive.org/web/20210615093249/https://www.brandeis.edu/rosenstiel/rosenstiel-award/index.html. June 15, 2021. January 30, 2021. www.brandeis.edu.
  35. Web site: March 12, 2021. 2020 Kavli Prize in Neuroscience. live. https://web.archive.org/web/20210624203359/https://kavliprize.org/prizes-and-laureates/prizes/2020-kavli-prize-neuroscience. June 24, 2021. June 23, 2021. www.kavliprize.org.
  36. Web site: Fundación BBVA. live. https://web.archive.org/web/20210130170154/https://www.fbbva.es/. January 30, 2021. January 30, 2021. FBBVA.
  37. Web site: The Nobel Prize in Physiology or Medicine 2021. October 4, 2021. NobelPrize.org. en-US. October 4, 2021. https://web.archive.org/web/20211004114036/https://www.nobelprize.org/prizes/medicine/2021/press-release/?related=1&_pjax=%23pjax-well. live.
  38. Web site: Armenian President congratulates Ardem Patapoutian on winning the Nobel Prize in Medicine. Public Radio of Armenia. October 4, 2021. October 5, 2021.
  39. Web site: Armenian President congratulates Ardem Patapoutian on winning the Nobel Prize in Medicine. October 15, 2021. Public Radio of Armenia. en-US.
  40. News: Nobel prize winner Ardem Patapoutian awarded Lebanese Order of Merit . . October 6, 2021 . https://web.archive.org/web/20211008124440/https://www.thenationalnews.com/mena/2021/10/06/nobel-prize-winner-ardem-patapoutian-awarded-lebanese-order-of-merit/ . October 8, 2021.
  41. Web site: Golden Plate Awardees of the American Academy of Achievement . www.achievement.org. American Academy of Achievement.
  42. Web site: Ardem Patapoutian . June 10, 2024 . Carnegie Corporation of New York.
  43. Web site: PM Pashinyan hosts Nobel Laureate Ardem Patapoutian, awards him with the Order of St. Mesrop Mashtots . The Office to the Prime Minister of the Republic of Armenia . https://web.archive.org/web/20220622120437/https://www.primeminister.am/en/press-release/item/2022/06/16/Nikol-Pashinyan-Nobel-Laureate-Ardem-Patapoutian/ . June 22, 2022 . June 16, 2022.
  44. Web site: Նոբելյան մրցանակի դափնեկիր Արտեմ Փաթափությանն ընտրվել է ՀՀ ԳԱԱ պատվավոր անդամ [Nobel Laureate Artem Pataputyan was elected an honorary member of the National Academy of Sciences of the Republic of Armenia] ]. sci.am . National Academy of Sciences of Armenia . https://web.archive.org/web/20220620164043/https://www.sci.am/newsview.php?id=539&langid=1 . June 20, 2022 . hy . June 14, 2022.
  45. Web site: First Armenian Nobel Prize winner Ardem Patapoutian is YSMU Honorary Doctor . Yerevan State Medical University . https://web.archive.org/web/20220622121528/https://ysmu.am/en/content/first_armenian_nobel_prize_winner_ardem_patapoutian_is_ysmu_honorary_doctor/ . June 22, 2022 . June 14, 2022.
  46. Web site: Patapoutian . Ardem . The 2nd (out of 3) replica medals has found a home at the History Museum of Armenia in Yerevan! . Twitter . https://archive.today/20220702115348/https://twitter.com/ardemp/status/1537140195514105862 . July 2, 2022 . June 15, 2022.
  47. News: Ghazanchyan . Siranush . Replica of Ardem Patapoutian's Nobel medal to be on display at History Museum of Armenia . . June 16, 2022 . https://web.archive.org/web/20220621102138/https://en.armradio.am/2022/06/16/replica-of-ardem-patapoutians-nobel-medal-to-be-displayed-at-history-museum-of-armenia/ . June 21, 2022.
  48. Web site: World famous Armenians. Ardem Patapoutian . stamps.am . . https://archive.today/20220701064339/https://www.stamps.am/all-issues/world-famous-armenians-ardem-patapoutian1655186543570165519192447916552006904501655269258275 . July 1, 2022 . June 14, 2022.

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