Archaeal translation explained

Archaeal translation is the process by which messenger RNA is translated into proteins in archaea. Not much is known on this subject, but on the protein level it seems to resemble eukaryotic translation.

Most of the initiation, elongation, and termination factors in archaea have homologs in eukaryotes.[1] Shine-Dalgarno sequences only are found in a minority of genes for many phyla, with many leaderless mRNAs probably initiated by scanning.[2] [3] [4] The process of ABCE1 ATPase-based recycling is also shared with eukaryotes.[5]

Being a prokaryote without a nucleus, archaea do perform transcription and translation at the same time like bacteria do.[6]

Further reading

Notes and References

  1. Saito K, Kobayashi K, Wada M, Kikuno I, Takusagawa A, Mochizuki M, Uchiumi T, Ishitani R, Nureki O, Ito K . 6 . Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis . Proceedings of the National Academy of Sciences of the United States of America . 107 . 45 . 19242–7 . November 2010 . 20974926 . 10.1073/pnas.1009599107 . 2984191 . 2010PNAS..10719242S . free .
  2. Book: Hernández, Greco,, Jagus, Rosemary. 9783319394688. Switzerland. 956539514. Hernández. Greco. Jagus. Rosemary. Evolution of the Protein Synthesis Machinery and Its Regulation . 2016-08-10 . 61–79 . Evolution of Translational Initiation: From Archaea to Eukarya . 10.1007/978-3-319-39468-8_4.
  3. Benelli . D . Londei . P . Translation initiation in Archaea: conserved and domain-specific features. . Biochemical Society Transactions . January 2011 . 39 . 1 . 89–93 . 10.1042/BST0390089 . 21265752.
  4. Nakagawa . S . Niimura . Y . Gojobori . T . Comparative genomic analysis of translation initiation mechanisms for genes lacking the Shine-Dalgarno sequence in prokaryotes. . Nucleic Acids Research . 20 April 2017 . 45 . 7 . 3922–3931 . 10.1093/nar/gkx124 . 28334743. 5397173 .
  5. Becker . T . Franckenberg . S . Wickles . S . Shoemaker . CJ . Anger . AM . Armache . JP . Sieber . H . Ungewickell . C . Berninghausen . O . Daberkow . I . Karcher . A . Thomm . M . Hopfner . KP . Green . R . Beckmann . R . Structural basis of highly conserved ribosome recycling in eukaryotes and archaea. . Nature . 22 February 2012 . 482 . 7386 . 501–6 . 10.1038/nature10829 . 22358840. 6878762 . 2012Natur.482..501B .
  6. French . S. L. . Santangelo . T. J. . Beyer . A. L. . Reeve . J. N. . Transcription and Translation are Coupled in Archaea . Molecular Biology and Evolution . 30 January 2007 . 24 . 4 . 893–895 . 10.1093/molbev/msm007. 17237472 . free .

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