Arachidonoyl serotonin explained

Arachidonoyl serotonin (N-arachidonoyl-serotonin, AA-5-HT) is an endogenous lipid signaling molecule. It was first described in 1998 as being an inhibitor of fatty acid amide hydrolase (FAAH).[1] In 2007, it was shown to have analgesic properties and to act as an antagonist of the TRPV1 receptor.[2] In 2011, it was shown to be present in the ileum and jejunum of the gastrointestinal tract and modulate glucagon-like peptide-1 (GLP-1) secretion.[3] In addition to this, in 2016, AA-5-HT was also found to affect the signaling mechanisms responsible for anxiety, by inhibiting dopamine release from the Basolateral amygdala following fear behavior.[4] In 2017, AA-5-HT was tested in its effects on the sleep wake cycle, where it was found to affect the sleep homeostasis when used in conjunction with molecules and chemicals that affect wake-related neurotransmitters.[5]

See also

Notes and References

  1. Bisogno . T. . Melck . D. . De Petrocellis . L. . Bobrov . M. U. . Gretskaya . N. M. . Bezuglov . V. V. . Sitachitta . N. . Gerwick . W. H. . Di Marzo . V. . Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase . Biochemical and Biophysical Research Communications . 248 . 3 . 515–522 . 1998 . 9703957 . 10.1006/bbrc.1998.8874.
  2. Maione . S. . De Petrocellis . L. . De Novellis . V. . Moriello . A. S. . Petrosino . S. . Palazzo . E. . Rossi . F. S. . Woodward . D. F. . Di Marzo . V. . 10.1038/sj.bjp.0707145 . Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors . British Journal of Pharmacology . 150 . 6 . 766–781 . 2007 . 17279090 . 2013858 .
  3. Verhoeckx . K. C. M. . Voortman . T. . Balvers . M. G. J. . Hendriks . H. F. J. . m.Wortelboer . H. . Witkamp . R. F. . 10.1016/j.bbalip.2011.07.008 . Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract . Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids . 1811 . 10 . 578–586 . 2011 . 21798367 .
  4. Freels. Timothy G.. Lester. Deranda B.. Cook. Melloni N.. 2019-04-19. Arachidonoyl serotonin (AA-5-HT) modulates general fear-like behavior and inhibits mesolimbic dopamine release. Behavioural Brain Research. en. 362. 140–151. 10.1016/j.bbr.2019.01.010. 30639609. 58578695. 0166-4328.
  5. Murillo-Rodríguez. Eric. Di Marzo. Vincenzo. Machado. Sergio. Rocha. Nuno B.. Veras. André B.. Neto. Geraldo A. M.. Budde. Henning. Arias-Carrión. Oscar. Arankowsky-Sandoval. Gloria. 2017. Role of N-Arachidonoyl-Serotonin (AA-5-HT) in Sleep-Wake Cycle Architecture, Sleep Homeostasis, and Neurotransmitters Regulation. Frontiers in Molecular Neuroscience. English. 10. 152. 10.3389/fnmol.2017.00152. 28611585. 5447686. 1662-5099. free.

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