| Acomayo River | |
| Name Etymology: | Quechua |
| Subdivision Type1: | Country |
| Subdivision Name1: | Peru |
| Subdivision Type3: | Region |
| Subdivision Name3: | Cusco Region |
| Mouth: | Apurímac River |
| Mouth Coordinates: | -13.9652°N -71.7418°W |
Acomayo River (possibly from Quechua aqu sand, mayu river,[1] "sand river") is a river in Peru, located in the Cusco Region, Acomayo Province, in the districts Acomayo and Acos. It is a right tributary of the Apurímac River. The confluence is southwest of the town Acomayo.