Aquaporin-8 Explained

Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene.^{[1] [2] [3]}

Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Harrington DJ, Adachi K, Royer WE . The high resolution crystal structure of deoxyhemoglobin S . J. Mol. Biol. . 272 . 3 . 398–407 . 1997 . 9325099 . 10.1006/jmbi.1997.1253 . free .
• Suzuki Y . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 . vanc. Yoshitomo-Nakagawa K . Maruyama K . 3 . Suyama . A . Sugano . S .
• Fischer H, Stenling R, Rubio C, Lindblom A . Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors . BMC Physiol. . 1. 1 . 2003 . 11231887 . 10.1186/1472-6793-1-1 . 32180 . free .
• Harrington JJ . Creation of genome-wide protein expression libraries using random activation of gene expression . Nat. Biotechnol. . 19 . 5 . 440–5 . 2001 . 11329013 . 10.1038/88107 . vanc. Sherf B . Rundlett S . 3 . Jackson . P. David . Perry . Rob . Cain . Scott . Leventhal . Christina . Thornton . Mark . Ramachandran . Rakesh . 25064683 .
• Wang S . Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption . Am. J. Obstet. Gynecol. . 185 . 5 . 1226–31 . 2001 . 11717661 . 10.1067/mob.[phone] . vanc. Kallichanda N . Song W . 3 . Ramirez . BA . Ross . MG .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wang S, Chen J, Au KT, Ross MG . Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells . Am. J. Obstet. Gynecol. . 188 . 4 . 997–1001 . 2003 . 12712100 . 10.1067/mob.[phone] .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Zahn A . Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis . World J. Gastroenterol. . 13 . 11 . 1687–95 . 2007 . 17461471 . 10.3748/wjg.v13.i11.1687. vanc. Moehle C . Langmann T . 3 . Ehehalt . R . Autschbach . F . Stremmel . W . Schmitz . G . 4146947 . free .

Notes and References

1. Koyama N, Ishibashi K, Kuwahara M, Inase N, Ichioka M, Sasaki S, Marumo F . Cloning and functional expression of human aquaporin8 cDNA and analysis of its gene . Genomics . 54 . 1 . 169–72 . Jan 1999 . 9806845 . 10.1006/geno.1998.5552 .
2. Viggiano L, Rocchi M, Svelto M, Calamita G . Assignment of the aquaporin-8 water channel gene (AQP8) to human chromosome 16p12 . Cytogenet Cell Genet . 84 . 3–4 . 208–10 . Jul 1999 . 10393433 . 10.1159/000015260 . 23854978 .
3. Web site: Entrez Gene: AQP8 aquaporin 8.