Aquaporin-7 Explained

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.^{[1] [2]}

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.

Further reading

• Dibas AI, Mia AJ, Yorio T . Aquaporins (water channels): role in vasopressin-activated water transport . Proc. Soc. Exp. Biol. Med. . 219 . 3 . 183–99 . 1998 . 9824541 . 10.3181/00379727-219-44332. 28952956 .
• Kuriyama H . Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability . Biochem. Biophys. Res. Commun. . 241 . 1 . 53–8 . 1998 . 9405233 . 10.1006/bbrc.1997.7769 . vanc. Kawamoto S . Ishida N . 3 . Ohno . Ikko . Mita . Shiro . Matsuzawa . Yuji . Matsubara . Kenichi . Okubo . Kousaku .
• Ishibashi K . Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping . Biochim. Biophys. Acta . 1399 . 1 . 62–6 . 1998 . 9714739 . 10.1016/s0167-4781(98)00094-3. vanc. Yamauchi K . Kageyama Y . 3 . Saito-Ohara . F . Ikeuchi . T . Marumo . F . Sasaki . S .
• Suzuki-Toyota F, Ishibashi K, Yuasa S . Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis . Cell Tissue Res. . 295 . 2 . 279–85 . 1999 . 9931374 . 10.1007/s004410051234 . 30916397 .
• Kondo H . Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation . Eur. J. Biochem. . 269 . 7 . 1814–26 . 2002 . 11952783 . 10.1046/j.1432-1033.2002.02821.x . vanc. Shimomura I . Kishida K . 3 . Kuriyama . Hiroshi . Makino . Yasunaka . Nishizawa . Hitoshi . Matsuda . Morihiro . Maeda . Norikazu . Nagaretani . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Humphray SJ . DNA sequence and analysis of human chromosome 9 . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . vanc. Oliver K . Hunt AR . 3 . Plumb . R. W. . Loveland . J. E. . Howe . K. L. . Andrews . T. D. . Searle . S. . Hunt . S. E. . 2004Natur.429..369H .
• Fortna A . Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution . PLOS Biol. . 2 . 7 . E207 . 2006 . 15252450 . 10.1371/journal.pbio.0020207 . 449870 . vanc. Kim Y . MacLaren E . 3 . Marshall . Kriste . Hahn . Gretchen . Meltesen . Lynne . Brenton . Matthew . Hink . Raquel . Burgers . Sonya . free .
• Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ . Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers . Biochem. Biophys. Res. Commun. . 339 . 3 . 785–9 . 2006 . 16325777 . 10.1016/j.bbrc.2005.11.080 .
• Prudente S . A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities . Diabetes . 56 . 5 . 1468–74 . 2007 . 17351148 . 10.2337/db06-1389 . vanc. Flex E . Morini E . 3 . Turchi . F. . Capponi . D. . De Cosmo . S. . Tassi . V. . Guida . V. . Avogaro . A. . free .
• Ceperuelo-Mallafré V . Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes . J. Clin. Endocrinol. Metab. . 92 . 9 . 3640–5 . 2007 . 17566090 . 10.1210/jc.2007-0531 . vanc. Miranda M . Chacón MR . 3 . Vilarrasa . N. . Megia . A. . Gutierrez . C. . Fernandez-Real . J. M. . Gomez . J. M. . Caubet . E. . free .

Notes and References

1. Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S . Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea . J Biol Chem . 272 . 33 . 20782–6 . Sep 1997 . 9252401 . 10.1074/jbc.272.33.20782 . free .
2. Web site: Entrez Gene: AQP7 aquaporin 7.