| Apure Department | |
| Native Name: | Departamento del Apure |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Subdivision Type: | Country |
| Subdivision Name: | Gran Colombia |
| Subdivision Type1: | District |
| Subdivision Name1: | Distrito del Norte |
| Coordinates: | 8.6333°N -82°W |
| Established Title: | Created |
| Established Date: | 1824 |
| Extinct Title: | Dissolved |
| Extinct Date: | 1830 |
| Seat Type: | Capital |
| Seat: | Barinas |
| Population Total: | 480,000 |
| Population As Of: | 1820 |
Apure Department was one of the departments of Gran Colombia. It was split from the Venezuela Department.
It encompassed 2 provinces - Barinas Province in the north and Achaguas Province in the south.