| Appignano | |
| Official Name: | Comune di Appignano |
| Coordinates: | 43.4°N 25°W |
| Region: | Marche |
| Province: | Macerata (MC) |
| Frazioni: | Forano |
| Mayor: | Osvaldo Messi |
| Area Total Km2: | 22.67 |
| Population Footnotes: | [1] |
| Population Total: | 4200 |
| Population As Of: | 30 November 2017 |
| Population Demonym: | Appignanesi |
| Elevation M: | 199 |
| Postal Code: | 62010 |
| Area Code: | 0733 |
Appignano is a comune (municipality) in the Province of Macerata in the Italian region Marche, located about 35km (22miles) southwest of Ancona and about 20km (10miles) northwest of Macerata.
Appignano borders the following municipalities: Cingoli, Filottrano, Macerata, Montecassiano, Montefano, Treia.
Sights include the church of San Giovanni.