| Jurisdiction: | Vicariate Apostolic |
| Izabal | |
| Latin: | Apostolicus Vicariatus Izabalensis |
| Country: | Guatemala |
| Province: | Exempt directly to the Holy See |
| Area Km2: | 9,038 |
| Population: | 419,000 |
| Population As Of: | 2010 |
| Catholics: | 280,000 |
| Catholics Percent: | 66.8 |
| Parishes: | 15 |
| Denomination: | Catholic Church |
| Sui Iuris Church: | Latin Church |
| Rite: | Roman Rite |
| Established: | 30 April 1968 (years ago) |
| Cathedral: | Catedral Inmaculada Concepción de María |
| Bishop Title: | Bishop |
| Bishop: | Domingo Buezo Leiva |
| Emeritus Bishops: | Gabriel Peñate Rodríguez |
| Map: | Guatemala - Vicariato apostolico di Izabal.png |
The Apostolic Vicariate of Izabal is a Latin Church ecclesiastical territory or apostolic vicariate of the Catholic Church in eastern Guatemala's Izabal Department. It is exempt directly to the Holy See and not part of any ecclesiastical province.
Its cathedral is Catedral Inmaculada Concepción de María, in the see of Puerto Barrios.
It was erected 30 April 1968, as the "Apostolic Administration of Izabal", on territory split off from the Diocese of Zacapa. It was elevated as an apostolic vicariate on 12 March 1988.