| Jurisdiction: | Apostolic Vicariate |
| Guapi | |
| Latin: | Apostolicus Vicariatus Guapiensis |
| Country: |  Colombia |
| Area Km2: | 10,000 |
| Population: | 132,000 |
| Population As Of: | 2010 |
| Catholics: | 128,000 |
| Catholics Percent: | 97 |
| Parishes: | 5 |
| Denomination: | Catholic Church |
| Rite: | Roman Rite |
| Established: | 5 April 1954 (years ago) |
| Cathedral: | Catedral de La Inmaculada Concepción |
| Bishop Title: | Vicar Apostolic |
| Emeritus Bishops: | Rafael Morales Duque, O.F.M. |
| Map: | Mapa Vicariato Apostolico de Guapi.svg |
The Vicariate Apostolic of Guapi (Latin: Apostolicus Vicariatus Guapiensis) in the Catholic Church is located in the town of Guapi, Cauca in Colombia.
On 5 April 1954 Pope Pius XII established the Prefecture Apostolic of Guapi from the Prefecture Apostolic of Tumaco. Blessed John Paul II elevated it to a Vicariate Apostolic on 13 February 2001.[1] [2]