Apolipoprotein L Explained

Apolipoprotein L (Apo L) is found in high-density lipoprotein complexes that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.^[1]

Human proteins containing this domain

APOL1

APOL2; APOL3; APOL4; APOL5; APOL6; APOLD1;

Notes and References

1. Arai H, Mimmack ML, Ryan M, Baba H, Navarro-ruiz J, Iritani S, Faull RL, Mckenna PJ, Jones PB, Starkey M, Emson PC, Bahn S . Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22 . Proc. Natl. Acad. Sci. U.S.A. . 99 . 7 . 4680–4685 . 2002 . 11930015 . 10.1073/pnas.032069099 . 123707. 2002PNAS...99.4680M . free .