Apo-beta-carotenoid-14',13'-dioxygenase explained

apo-beta-carotenoid-14',13'-dioxygenase
Ec Number:	1.13.11.67
Go Code:	0050588

Apo-beta-carotenoid-14',13'-dioxygenase (is an enzyme that catalyzes the chemical reaction

8'-apo-beta-carotenol + O₂

\rightleftharpoons 14'-apo-beta-carotenal + uncharacterized product

Thus, the two substrates of this enzyme are 8'-apo-beta-carotenol and oxygen, whereas its two products are 14'-apo-beta-carotenal and an uncharacterized product that may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O₂ as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O with incorporation of one atom of oxygen (internal monooxygenases o internal mixed-function oxidases). The systematic name of this enzyme class is 8'-apo-beta-carotenol:O2 oxidoreductase.

References

• 32747548 . 2020 . Daruwalla . A. . Zhang . J. . Lee . H. J. . Khadka . N. . Farquhar . E. R. . Shi . W. . von Lintig . J. . Kiser . P. D. . Structural basis for carotenoid cleavage by an archaeal carotenoid dioxygenase . Proceedings of the National Academy of Sciences of the United States of America . 117 . 33 . 19914–19925 . 10.1073/pnas.2004116117 . 7443882 . 2020PNAS..11719914D . free .
• Dmitrovskii AA, Gessler NN, Gomboeva SB . Enzymatic oxidation of beta-apo-8'-carotenol to beta-apo-14'-carotenal by an enzyme different from beta-carotene-15,15'-dioxygenase . Biochemistry. Biokhimiia . 62 . 7 . 787–92 . July 1997 . 9331970 .