| Central College, Anuradhapura | |
| Native Name: | මධ්ය විද්යාලය, අනුරාධපුර |
| Motto: | අසමු දරමු හැසිරෙමු "Harken Memorise Act" |
| City: | Anuradhapura |
| Postcode: | 50000 |
| Country: | Sri Lanka |
| Coordinates: | 8.3352°N 80.4075°W |
| Type: | Started as a non profit organisation, currently State run |
| Established: | 1947 |
| Founder: | R. L. N. de Zoyza |
| Head: | Percy Mahanaama Jayasundara (2022-Present) |
| Grades: | 6–13 |
| Head Label: | Principal |
| Students: | 5000 |
| Colors: | Dark green and yellow |
Anuradhapura Central College (Sinhala; Sinhalese: මධ්ය විද්යාලය, අනුරාධපුර, Tamil: மத்திய கல்லூரி, அனுராதபுரம்) is a mixed educational establishment in North Central Province, Sri Lanka.Anuradhapura Central College is a national school, which provides secondary education.
Anuradhapura Central College, which is considered as the heart of Anuradhapura, is situated in Anuradhapura, the capital city of North Central Province, Sri Lanka. It was established on 21 July 1947 under the initiative of R. L. N. de Zoyza in Rathmale area where the Rathmale Tissa Vidyalaya is situated today.
It was established to provide free education by the Minister of Education, Dr. C. W. W. Kannangara. It was the second Central College established in the North Central Province and one of the first 54 Central Colleges in the country. De Zoysa was the first principal and there were only seven teachers and twenty students in the school.
The school was later moved to its present location. In 1993 the school was promoted to a National School under the leadership of the then principal E. R. Erathna. In 2014, H. M. Abeykoon was appointed as the principal of the college, with a staff of 190 teachers and 4,800 students.Present principal of Anuradhapura Central College is Mr. J.M.P.M. Jayasundara.
The College motto is "Asamu Daramu Haesirmu", meaning "Harken Memorise Act" in Sinhala. Its nickname is "Emeralds"
Namadimu baethi gee kusum puda is the school song, which is sung at the start of the school day and on important occasions.
The students are divided in to four houses, which are named after four great arahant theros. An annual track-and-field tournament among these houses is held during the first term of the academic year.
Anuradhapura Central College has produced graduates in many fields such as engineering, medicine, law, politics, education, administration, mass-media and entertainment, including: