| Official Name: | Antofagasta de la Sierra |
| Pushpin Map: | Argentina |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Argentina |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Name1: | Catamarca |
| Subdivision Type2: | Department |
| Subdivision Name2: | Antofagasta de la Sierra |
| Subdivision Type3: | 3rd level Municipality |
| Subdivision Name3: | Antofagasta de la Sierra |
| Population Total: | 667 |
| Coordinates: | -26.0667°N -92°W |
| Elevation M: | 3320 |
| Postal Code Type: | CPA Base |
| Postal Code: | K 4704 |
| Area Code: | +54 3835 |
Antofagasta de la Sierra is a village in Catamarca Province, Argentina. It is the head town of the Antofagasta de la Sierra Department.
Antofagasta de la Sierra is a high altitude settlement, the majority of its inhabitants are descended from the Diaguitas and Atacameños.
The local economy is based on agriculture and farming; the residents keep sheep and llama and grow vegetables. Tourism plays an important part in the local economy as many tourists come to see the nearby mountains, volcanoes and calderas, including Galán caldera and the Antofagasta de la Sierra volcanic field. The village holds an annual Festival of the dead.