| Antigonish—Guysborough | |
| Province: | Nova Scotia |
| Fed-Status: | defunct |
| Fed-Created: | 1914 |
| Fed-Abolished: | 1966 |
| Fed-Election-First: | 1917 |
| Fed-Election-Last: | 1965 |
Antigonish—Guysborough was a federal electoral district in Nova Scotia, Canada, that was represented in the House of Commons of Canada from 1917 to 1968.
This riding was created in 1914 and combined the former ridings of Antigonish and Guysborough. Antigonish—Guysborough was abolished under redistribution in 1966 forming parts of Cape Breton Highlands—Canso and Central Nova.
This riding has elected the following members of Parliament: