Antibe Therapeutics Explained

Antibe Therapeutics Inc.
Type:	Publicly traded corporation
Location City:	Toronto
Location Country:	Canada
Key People:	Dan Legault JD, CEO; Alain Wilson, CFO; Dr. John L. Wallace, Chief Scientific Officer; Joseph Stauffer, Chief Medical Officer
Industry:	Pharmaceuticals

Antibe Therapeutics was a Toronto-based pharmaceutical company that develops pain and inflammation-reducing drugs based on gaseous mediator technology.^[1] Antibe was founded by John L. Wallace, also a co-founder of NicOx, the first company to develop drugs utilizing gaseous mediators. Founded in 2009, the company listed on the TSX Venture Exchange in 2013 and was moved to the Toronto Stock Exchange in November 2020. In 2015, Antibe acquired Citagenix, a distributor involved in regenerative medicine.^[2]

On June 1, 2020, the company announced positive results in the final Phase 2 trial of its first drug Otenaproxesul.^[3]

On March 29, 2021, the drug's Investigational New Drug application was cleared by the US Food and Drug Administration, allowing for human trials.^[4]

In May 2024 the company went bankrupt and its stock was delisted from the Toronto Stock Exchange.

Products

The mechanism of action of Antibe's drugs is the delivery of minute amounts of hydrogen sulfide to sites of inflammation within the human body.^[5] Hydrogen sulfide has been shown to enhance the resolution of injury and repair of damage arising from tissue inflammation.^[6]

Antibe's lead drug, Otenaproxesul (formerly ATB-346, now known by its International Nonproprietary Name), is a hydrogen sulfide-releasing derivative of naproxen, a commonly used non-steroidal anti-inflammatory drug (NSAID). Otenaproxesul is being developed as a safer non-opiod analgesic for acute pain. Antibe is targeting the post-operative pain market and plans to broaden its application to include migraines, dysmenorrhea and dental pain. Unlike standard naproxen, Otenaproxesul does not induce damage to the gastrointestinal tract.^[7] In May 2014, the company announced that it had completed pre-clinical studies on Otenaproxesul.^[8] In late June 2014, following approval from Health Canada, the company announced the first human dosing for Phase I of its human clinical trials.^[9] In mid-January 2015, the company announced that clinical trials for Otenaproxesul were being suspended due to safety concerns; clinical trials were restarted in March 2015.^[10]

On March 20, 2018, Antibe Therapeutics announced successful results for Phase 2B gastrointestinal safety study for Otenaproxesul.^[11] On June 1, 2020, Antibe announced positive results for Otenaproxesul in its final Phase 2 trial – a dose ranging, efficacy study.^[12] The company's second drug, an opioid-replacement for post-surgical pain, is expected to start clinical trials in late 2023.^[13]

On November 12, 2020, Antibe Therapeutics has moved to the TSX. In February 2021, Antibe announced a deal with Nuance Pharma, a Chinese pharmaceutical company, entitling them to $100 million in funding, with $20 million upfront.^[14]

People

Antibe's science advisory board:^[15]

• Andre G. Buret, Professor, University of Calgary, Canada
• Giuseppe Cirino, PhD, Professor, University of Naples, Italy
• Gilberto de Nucci, MD, PhD, Professor, University of São Paulo, Brazil
• Peter B. Ernst, DVM, PhD, Professor, UCSD, San Diego, USA
• Derek Gilroy, PhD, Professor, University College, London, UK
• Richard H. Hunt, MD, Emeritus Professor, McMaster University, Canada
• Louis Ignarro, PhD Professor, UCLA, Los Angeles, USA - 1998 Nobel Prize Laureate in Medicine
• Daniel K. Podolsky, MD, President, University of Texas Southwestern Medical Center, USA
• William Sessa, PhD, Professor, Yale University, USA
• Philip M. Sherman, MD, Professor, University of Toronto, Canada

Antibe's board of directors:^[16]

• Chair - Walt Macnee, Vice Chair, MasterCard International^[17]
• Roderick Flower, Professor Emeritus, Barts and The London School of Medicine and Dentistry
• Dan Legault, CEO, Antibe Therapeutics
• Robert Hoffman, former CFO, Heron Therapeutics; Director, public biotechnology companies
• Amal Khouri, VP Business Development, Knight Therapeutics^[18]
• Jennifer McNealey, VP Investor Relations and Strategy, Calithera Biosciences
• John L. Wallace, Chief Scientific Officer, Antibe Therapeutics
• Yung Wu, CEO, MaRS Discovery District^[19]

External links

• Biotechnology Focus: The Need for a Safer NSAID: Can Antibe Therapeutics Deliver One? http://biotechnologyfocus.ca/the-need-for-a-safer-nsaid-can-ontarios-antibe-therapeutics-deliver-one
• Third International Conference on Medical & Biological Uses of Hydrogen Sulfide Third International Conference on Hydrogen Sulfide in Biology and Medicine (H2S 2014)

Notes and References

1. Web site: Antibe Therapeutics. 2021-11-23. 2021-11-17. https://web.archive.org/web/20211117174809/https://antibethera.com/. live.
2. Web site: Stocks . . 2021-11-23 . 2017-12-17 . https://web.archive.org/web/20171217041203/https://www.bloomberg.com/research/stocks/news/article.asp?docKey=600-201602021810BIZWIRE_USPRX____BW6697-1&ex=true&ticker=MNK . live .
3. Web site: Antibe's Non-Opioid Pain Drug Otenaproxesul Looks Good in Phase IIb Trials. August 5, 2020. American Council on Science and Health. November 23, 2021. June 26, 2021. https://web.archive.org/web/20210626000906/https://www.acsh.org/news/2020/08/05/antibes-non-opioid-pain-drug-otenaproxesul-looks-good-phase-iib-trials-14951. live.
4. Web site: Antibe Therapeutics Receives FDA Clearance of IND Application for Otenaproxesul for Osteoarthritis Pain. 2021-03-21. American Council on Science and Health. 2023-06-01. 2023-06-01. https://web.archive.org/web/20230601160716/https://stockhouse.com/news/press-releases/2021/03/29/antibe-therapeutics-receives-fda-clearance-of-ind-application-for-otenaproxesul. live.
5. Web site: Why Hydrogen Sulfide? – Antibe Therapeutics. 21 August 2019 . 2021-11-23. 2021-08-12. https://web.archive.org/web/20210812162342/https://antibethera.com/science/why-h2s/. live.
6. Book: 26162834 . 10.1007/978-3-319-18144-8_8 . H2S and Inflammation: An Overview . 2015 . Handbook of Experimental Pharmacology . 165–180. Bhatia . Madhav . Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide . 230 . 978-3-319-18143-1 .
7. British Journal of Pharmacology 30834513 . 10.1111/bph.14641 . 177 . 4 . A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug. . February 2019 . Br J Pharmacol . 769–777. 7024706 . Wallace . John L. . Nagy . Peter . Feener . Troy D. . Allain . Thibault . Ditrói . Tamás . Vaughan . David J. . Muscara . Marcelo N. . Nucci . Gilberto . Buret . Andre G. .
8. https://www.wsj.com/article/PR-CO-20140505-901386.html{{Dead link|date=January 2022 |bot=InternetArchiveBot |fix-attempted=yes }}
9. Web site: Antibe Therapeutics Announces First Human Dose of ATB-346 in Phase I Clinical Trial - MarketWatch . 2014-06-27 . 2014-07-14 . https://web.archive.org/web/20140714163704/http://www.marketwatch.com/story/antibe-therapeutics-announces-first-human-dose-of-atb-346-in-phase-i-clinical-trial-2014-06-26 . live .
10. Web site: Antibe Therapeutics Provides an Update on its Data Review and Corporate Strategy – Antibe Therapeutics. 11 March 2015 . 2021-11-23. 2021-04-16. https://web.archive.org/web/20210416085233/https://antibethera.com/news/antibe-therapeutics-provides-an-update-on-its-data-review-and-corporate-strategy/. live.
11. Web site: Antibe Therapeutics Announces Successful Phase 2B Gastrointestinal Safety Study for Lead Pain Drug, ATB-346 – Antibe Therapeutics. 20 March 2018 . 2021-11-23. 2021-04-16. https://web.archive.org/web/20210416072405/https://antibethera.com/news/antibe-therapeutics-announces-successful-phase-2b-gastrointestinal-safety-study-for-lead-pain-drug-atb-346/. live.
12. Web site: Antibe Therapeutics Announces Positive Top-Line Data from Phase 2B Dose-Ranging, Efficacy Study for ATB-346 – Antibe Therapeutics. June 2020 . 2021-11-23. 2021-02-25. https://web.archive.org/web/20210225111126/https://antibethera.com/news/antibe-therapeutics-announces-positive-top-line-data-from-phase-2b-dose-ranging-efficacy-study-for-atb-346/. live.
13. Web site: Antibe Therapeutics Provides Corporate Update – Antibe Therapeutics. 4 August 2020 . 2021-11-23. 2021-05-28. https://web.archive.org/web/20210528140352/https://antibethera.com/news/antibe-therapeutics-provides-corporate-update/. live.
14. Web site: Antibe Therapeutics inks licensing deal with Nuance Pharma. www.biospectrumasia.com.
15. Web site: Scientific Advisory Board – Antibe Therapeutics. 22 July 2019 . 2021-11-23. 2021-08-12. https://web.archive.org/web/20210812220737/https://antibethera.com/about-us/scientific-advisory-board/. live.
16. Web site: Board of Directors – Antibe Therapeutics. 28 August 2019 . 2021-11-23. 2021-08-13. https://web.archive.org/web/20210813090251/https://antibethera.com/about-us/board-of-directors/. live.
17. Web site: Mastercard Incorporated - Investor Relations. investor.mastercard.com. 2021-11-23. 2021-11-22. https://web.archive.org/web/20211122191709/https://investor.mastercard.com/overview/default.aspx. live.
18. Web site: Knight Therapeutics – Building a leading specialty pharmaceutical company . 2021-11-23 . 2020-09-25 . https://web.archive.org/web/20200925214957/https://gud-knight.com/category/management-team/ . live .
19. Web site: About MaRS. MaRS Discovery District. 2021-11-23. 2021-11-19. https://web.archive.org/web/20211119192420/https://marsdd.com/about/. live.