| Antônio Souza | |
| Full Name: | Antônio Delfino de Souza |
| Birth Place: | Redenção do Gurguéia, Brazil |
| Height: | 174 cm |
| Weight: | 69 kg |
| Sport: | Para athletics |
| Event: | Sprint |
| Disability Class: | T46 |
Antônio Delfino de Souza (born 11 August 1971) is a retired paralympic sprinter from Brazil. At the age of 17 de Souza had his right hand amputated after an accident at agricultural works. In 1992, he moved to Brasília, where he took up sprint running. He competed in T46 sprint events at the 2000, 2004, 2008 and 2012 Paralympics and won two gold and one silver medal in 2000 and 2004. He was selected as a final Paralympic torch bearer at the 2016 Summer Paralympics opening ceremony.