| Honorific-Prefix: | Count |
| António Teixeira de Sousa | |
| Office4: | Prime Minister of Portugal |
| Term Start4: | 26 June 1910 |
| Term End4: | 5 October 1910 |
| Monarch4: | Manuel II |
| Predecessor4: | Francisco da Veiga Beirão |
| Successor4: | Provisional Government |
| Birth Date: | 5 May 1857 |
| Birth Place: | Celeirós, Sabrosa, Kingdom of Portugal |
| Death Place: | Celeirós, Sabrosa, Portuguese Republic |
| Party: | Regenerator Party |
| Occupation: | Medical doctor Thermae doctor Writer |
António Teixeira de Sousa, 2nd Count of Sousa Palmela (pronounced as /pt/; 5 May 1857 in Celeirós, Sabrosa – 5 June 1917 in Celeirós, Sabrosa) was a Portuguese medical doctor and politician during the Constitutional Monarchy. He graduated in Medicine at the University of Porto, in 1883. A member of the conservative Regenerator Party, he was first elected to the Chamber of Deputies, in 1889. He was later minister of the Navy and Overseas (1900–1903), and, twice, of Finance (1903–1904, 1906). He became President of the Council of Ministers (Prime Minister) on 26 June 1910, and would be the last Prime Minister of the Constitutional Monarchy as King D. Manuel II was overthrown by a republican revolution on 5 October 1910. He left politics after the republic proclamation, but showed a moderate support for the new regime.