| Ano Simi | |
| Native Name Lang: | el |
| Other Name: | Epano Simi |
| Settlement Type: | Village |
| Flag Border: | no |
| Pushpin Map: | Greece |
| Pushpin Map Caption: | Location in Greece |
| Subdivision Type: | Country |
| Subdivision Name: |  Greece |
| Subdivision Type1: | Prefecture |
| Subdivision Name1: | Lasithi |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Ierapetra |
| Elevation M: | 900 |
| Timezone1: | Eastern European Time |
| Utc Offset1: | +2 |
| Timezone1 Dst: | Eastern European Summer Time |
| Utc Offset1 Dst: | +3 |
Ano Simi is a village on Crete in the prefecture of Lasithi. It is part of Ierapetra municipality and borders Viannos municipality. It lies about 900 meters above sea level, south of Mount Dikti in what is probably the most wooded area of Crete. It is about 1 kilometer from Kato Simi, and 32 kilometers from Ierapetra.