Annular elastolytic giant-cell granuloma explained

Annular elastolytic giant-cell granuloma

Annular elastolytic giant-cell granuloma (also known as "Giant cell elastophagocytosis," "Meischer's granuloma," "Miescher's granuloma of the face"[1]) is a cutaneous condition characterized histologically by a dermal infiltrate of macrophages.[1] [2]

Signs and symptoms

The most common presentation of annular elastolytic giant-cell granuloma is one or more annular or ring-shaped patches with elevated borders, atrophy, and central hypopigmentation. Generalized papular lesions may also be observed.[3] [4] Although it sporadically affects covered areas as well, annular elastolytic giant-cell granuloma is generally thought to be a disease that primarily affects sun-exposed areas.[5] [6]

Diagnosis

Histopathologically, an annular elastolytic giant-cell granuloma exhibits a granulomatous reaction accompanied by phagocytosis of the elastic fibers, elastolysis,  and multinucleate giant cells devoid of or reduced in elastin fibers. Other hallmarks of the histopathology include the lack of mucin deposition and collagen necrobiosis.[7]

Treatment

The handling of these cases is debatable, with differing results from topical treatments using tacrolimus, retinoids, and corticosteroids, and systemic treatments using methotrexate, isotretinoin, clofazimine, acitretin, and hydroxychloroquine.[8]

See also

External links

Notes and References

  1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
  2. Book: James, William D. . Berger, Timothy G. . Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier . 2006 . 978-0-7216-2921-6 . etal.
  3. Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine . British Journal of Dermatology . Oxford University Press (OUP) . 140 . 3 . 1999 . 0007-0963 . 10.1046/j.1365-2133.1999.02723.x . 525–530 . Özkaya-Bayazit . Büyükbabani̇ . Baykal . Öztürk . Okçu . Soyer . 10233280 . 23145183 .
  4. Rongioletti . F. . Baldari . M. . Burlando . M. . Parodi . A. . Papular elastolytic giant cell granuloma: report of a case associated with monoclonal gammopathy and responsive to topical tacrolimus . Clinical and Experimental Dermatology . Oxford University Press (OUP) . 35 . 2 . 2010 . 0307-6938 . 10.1111/j.1365-2230.2008.03129.x . 145–148. 19508563 . 19674767 .
  5. Ishibashi . Akira . Yokoyama . Aiko . Hirano . Kyoko . Annular Elastolytic Giant Cell Granuloma Occurring in Covered Areas . Dermatology . S. Karger AG . 174 . 6 . 1987 . 1018-8665 . 10.1159/000249202 . 293–297. 3622881 .
  6. Muramatsu . Tsutomu . Shirai . Toshihiko . Yamashina . Yukio . Sakamoto . Kuniki . Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Lesions Arising in Non-sun-exposed Areas . The Journal of Dermatology . Wiley . 14 . 1 . 1987 . 0385-2407 . 10.1111/j.1346-8138.1987.tb02996.x . 54–58. 3301949 . 31861362 .
  7. Arora . Sandeep . Malik . Ajay . Patil . Chetan . Balki . Anil . Annular elastolytic giant cell granuloma: A report of 10 cases . Indian Dermatology Online Journal . Medknow . 6 . 7 . 2015 . S17-20 . 2229-5178 . 10.4103/2229-5178.171055 . free . 26904442 . 4738508 .
  8. Babuna . Goncagul . Buyukbabani . Nesimi . Yazganoglu . KDidem . Baykal . Can . Effective treatment with hydroxychloroquine in a case of annular elastolytic giant cell granuloma . Indian Journal of Dermatology, Venereology and Leprology . Scientific Scholar . 77 . 1 . 2011 . 110–111 . 0378-6323 . 10.4103/0378-6323.74988 . free . 21220900 .

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