Annexin A11 Explained

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.

Interactions

ANXA11 has been shown to interact with PDCD6^[4] and ALG2.^[5]

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder.^[6]

Further reading

• Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H . Specific binding of CAP-50 to calcyclin . FEBS Letters . 305 . 3 . 217–9 . Jul 1992 . 1299619 . 10.1016/0014-5793(92)80671-3 . 41323727 . free .
• Dawson SJ, White LA . Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin . The Journal of Infection . 24 . 3 . 317–20 . May 1992 . 1602151 . 10.1016/S0163-4453(05)80037-4 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Sjölin C, Dahlgren C . Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI . Blood . 87 . 11 . 4817–23 . Jun 1996 . 8639854 . 10.1182/blood.V87.11.4817.bloodjournal87114817. free .
• Brownawell AM, Creutz CE . Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII) . The Journal of Biological Chemistry . 272 . 35 . 22182–90 . Aug 1997 . 9268363 . 10.1074/jbc.272.35.22182 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Sudo T, Hidaka H . Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis . FEBS Letters . 444 . 1 . 11–4 . Feb 1999 . 10037139 . 10.1016/S0014-5793(99)00014-9 . 25762914 .
• Bances P, Fernandez MR, Rodriguez-Garcia MI, Morgan RO, Fernandez MP . Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms . Genomics . 69 . 1 . 95–103 . Oct 2000 . 11013079 . 10.1006/geno.2000.6309 .
• Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M . ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner . Biochemical and Biophysical Research Communications . 291 . 5 . 1166–72 . Mar 2002 . 11883939 . 10.1006/bbrc.2002.6600 .
• Satoh H, Nakano Y, Shibata H, Maki M . The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1600 . 1–2 . 61–7 . Nov 2002 . 12445460 . 10.1016/S1570-9639(02)00445-4 .
• Breen EC, Tang K . Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro . Journal of Cellular Biochemistry . 88 . 4 . 848–54 . Mar 2003 . 12577318 . 10.1002/jcb.10398 . 23949602 .
• Tomas A, Moss SE . Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope . The Journal of Biological Chemistry . 278 . 22 . 20210–6 . May 2003 . 12601007 . 10.1074/jbc.M212669200 . free . 10044/1/42329 . free .
• Farnaes L, Ditzel HJ . Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display . The Journal of Biological Chemistry . 278 . 35 . 33120–6 . Aug 2003 . 12805373 . 10.1074/jbc.M210852200 . free.
• Tomas A, Futter C, Moss SE . Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis . The Journal of Cell Biology . 165 . 6 . 813–22 . Jun 2004 . 15197175 . 2172404 . 10.1083/jcb.200311054 .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Misaki Y, Pruijn GJ, van der Kemp AW, van Venrooij WJ . The 56K autoantigen is identical to human annexin XI . The Journal of Biological Chemistry . 269 . 6 . 4240–6 . Feb 1994 . 10.1016/S0021-9258(17)41769-8 . 7508441 . free .
2. Morgan RO, Bell DW, Testa JR, Fernandez MP . Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins . Genomics . 48 . 1 . 100–10 . Feb 1998 . 9503022 . 10.1006/geno.1997.5148 .
3. Web site: Entrez Gene: ANXA11 annexin A11.
4. Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M . ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner . Biochemical and Biophysical Research Communications . 291 . 5 . 1166–72 . Mar 2002 . 11883939 . 10.1006/bbrc.2002.6600 .
5. Satoh H, Nakano Y, Shibata H, Maki M . The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics . 1600 . 1–2 . 61–7 . Nov 2002 . 12445460 . 10.1016/S1570-9639(02)00445-4 .
6. Ghazaryan H . Annexin 11 expression pattern in schizophrenia . Electronic Journal of Natural Sciences . 21 . 2 . 74–76 . Jul 2013 .