Anneke Brand Explained

Anneke Brand
Birth Date:7 June 1946
Birth Place:The Hague, Netherlands
Death Date:2021
Fields:Medicine, Transfusion Medicine, Hematology

Anneke Brand (1946-2021) was a Dutch physician-scientist whose work on platelet and red blood cell transfusion and cord blood transplantation earned her transfusion medicine’s three highest honors: the AABB Karl Landsteiner Memorial Award; International Society of Blood Transfusion Presidential Award; and the British Blood Transfusion Society James Blundell Award.

Early life and education

Brand was born on 7 June 1946 in The Hague, the Netherlands. In 1973, she obtained her medical degree from the Free University Amsterdam. Brand earned her Ph.D. in 1978 from the Leiden Academic Hospital under Professors Jon van Rood[1] and George Eernisse, on the topic of ‘Platelet Supportive Care’. Brand trained in internal medicine in Haarlem and in haematology at the Leiden Academic Hospital.[2]

Career

Brand studied the management of platelet refractoriness[3] and the role of leukocytes[4] [5] in erythrocyte alloimmunization[6] [7] [8] and transfusion outcomes. She helped establish the need for leukoreduction to diminish transfusion reactions.[9] [10] She studied the optimal conditions for the storage and expansion of cord blood[11] for transplantation, along with platelets[12] and red cells[13] [14] for transfusion.

Brand developed peri-operative blood management strategies[15] [16] and co-directed clinical platelet transfusion trials.[17] [18] [19] [20] She studied non-inherited maternal antigens[21] [22] [23] and factors that influence erythrocyte alloimmunization.[24] [25] She was the senior author on the MATCH study, which looked at whether red cell units should be matched only for ABO and RhD, or for additional erythrocyte antigens such as c, C, E, K, Fy(a), Jk(a), and S.[26]

Brand co-authored over 350 papers, helped found the Dutch Cord Blood Bank, served on the board of the European Hematology Association from 2011 to 2015,[27] and helped develop educational programs for training physicians and laboratory technologists.[28] [29]

Awards

Notes and References

  1. Jager . Martine J. . Brand . Anneke . Claas . Frans H. J. . 2019 . Jon van Rood: The pioneer and his personal view on the early developments of HLA and immunogenetics . Transplant Immunology . 52 . 1–26 . 10.1016/j.trim.2018.12.006 . 1878-5492 . 30611771 . free.
  2. Kerkhoffs . Jean-Louis H. . So-Osman . Cynthia . Anneke Brand (1946–2021) . Vox Sanguinis . 117 . 1 . 2022 . 0042-9007 . 10.1111/vox.13231 . free . 149–150. 34918352 .
  3. Kerkhoffs . Jean-Louis H. . Eikenboom . Jeroen C. J. . van de Watering . Leo M. G. . van Wordragen-Vlaswinkel . Rinie J. . Wijermans . Pierre W. . Brand . Anneke . 2008 . The clinical impact of platelet refractoriness: correlation with bleeding and survival . Transfusion . 48 . 9 . 1959–1965 . 10.1111/j.1537-2995.2008.01799.x . 1537-2995 . 18564396.
  4. Bilgin . Yavuz M. . van de Watering . Leo M. G. . Versteegh . Michel I. M. . van Oers . Marinus H. J. . Brand . Anneke . 2010 . Effects of allogeneic leukocytes in blood transfusions during cardiac surgery on inflammatory mediators and postoperative complications . Critical Care Medicine . 38 . 2 . 546–552 . 10.1097/CCM.0b013e3181c0de7b . 1530-0293 . 19864941.
  5. Schonewille . Henk . Brand . Anneke . 2005 . Alloimmunization to red blood cell antigens after universal leucodepletion. A regional multicentre retrospective study . British Journal of Haematology . 129 . 1 . 151–156 . 10.1111/j.1365-2141.2005.05408.x . 0007-1048 . 15801967.
  6. Natukunda . Bernard . Schonewille . Henk . Ndugwa . Christopher . Brand . Anneke . 2010 . Red blood cell alloimmunization in sickle cell disease patients in Uganda . Transfusion . 50 . 1 . 20–25 . 10.1111/j.1537-2995.2009.02435.x . 1537-2995 . 19821949.
  7. Schonewille . Henk . de Vries . Rene R. P. . Brand . Anneke . 2009 . Alloimmune response after additional red blood cell antigen challenge in immunized hematooncology patients . Transfusion . 49 . 3 . 453–457 . 10.1111/j.1537-2995.2008.01980.x . 1537-2995 . 19243541.
  8. Schonewille . Henk . van de Watering . Leo M. G. . Loomans . Dominique S. E. . Brand . Anneke . 2006 . Red blood cell alloantibodies after transfusion: factors influencing incidence and specificity . Transfusion . 46 . 2 . 250–256 . 10.1111/j.1537-2995.2006.00708.x . 0041-1132 . 16441603.
  9. van de Watering . Leo . Hermans . Jo . Witvliet . Marian . Versteegh . Michel . Brand . Anneke . 2003 . HLA and RBC immunization after filtered and buffy coat-depleted blood transfusion in cardiac surgery: a randomized controlled trial . Transfusion . 43 . 6 . 765–771 . 10.1046/j.1537-2995.2003.00390.x . 0041-1132 . 12757528.
  10. Brand . Anneke . 2002 . Immunological aspects of blood transfusions . Transplant Immunology . 10 . 2–3 . 183–190 . 10.1016/s0966-3274(02)00064-3 . 0966-3274 . 12216948.
  11. Brand . Anneke . Eichler . Hermann . Szczepiorkowski . Zbigniew M. . Hess . van de Watering . Leo M. G. . Biomedical Excellence for Safer Transfusion (BEST) Collaborative . 2008 . Viability does not necessarily reflect the hematopoietic progenitor cell potency of a cord blood unit: results of an interlaboratory exercise . Transfusion . 48 . 3 . 546–549 . 10.1111/j.1537-2995.2007.01568.x . 0041-1132 . 18067495.
  12. Kerkhoffs . Jean-Louis H. . Eikenboom . Jeroen C. . Schipperus . Martin S. . Brand . Anneke . 2006-11-01 . A multicenter randomized study of the efficacy of transfusions with platelets stored in platelet additive solution II versus plasma . Blood . 108 . 9 . 3210–3215 . 10.1182/blood-2006-04-020131 . 0006-4971 . 16825492 . free.
  13. van de Watering . Leo M. G. . Brand . Anneke . 2008 . Effects of storage of red cells . Transfusion Medicine and Hemotherapy: Offizielles Organ der Deutschen Gesellschaft Fur Transfusionsmedizin und Immunhamatologie . 35 . 5 . 359–367 . 10.1159/000155221 . 1660-3796 . 3076328 . 21512625 . free.
  14. van de Watering . Leo . Lorinser . Jos . Versteegh . Michel . Westendord . Rudi . Brand . Anneke . 2006 . Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients . Transfusion . 46 . 10 . 1712–1718 . 10.1111/j.1537-2995.2006.00958.x . 0041-1132 . 17002627.
  15. So-Osman . Cynthia . Nelissen . Rob G. H. H. . Koopman-van Gemert . Ankie W. M. M. . Brand . Ronald . Brand . Anneke . 2014 . Patient blood management in elective total hip- and knee-replacement surgery (part 2): a randomized controlled trial on blood salvage as transfusion alternative using a restrictive transfusion policy in patients with a preoperative hemoglobin above 13 g/dl . Anesthesiology . 120 . 4 . 852–860 . 10.1097/ALN.0000000000000135 . 1528-1175 . 24434302.
  16. So-Osman . Cynthia . Nelissen . Rob G. H. H. . Koopman-van Gemert . Ankie W. M. M. . Brand . Ronald . Brand . Anneke . 2014 . Patient blood management in elective total hip- and knee-replacement surgery (Part 1): a randomized controlled trial on erythropoietin and blood salvage as transfusion alternatives using a restrictive transfusion policy in erythropoietin-eligible patients . Anesthesiology . 120 . 4 . 839–851 . 10.1097/ALN.0000000000000134 . 1528-1175 . 24424070 . free.
  17. Saris . Anno . Tomson . Bert . Brand . Anneke . Mulder . Arend . van der Meer . Pieter F. . 2018-01-04 . Platelets from donors with consistently low HLA-B8, -B12, or -B35 expression do not undergo antibody-mediated internalization . Blood . 131 . 1 . 144–152 . 10.1182/blood-2017-07-799270 . 1528-0020 . 29092829 . free.
  18. van Hout . Fabienne M. A. . Hogervorst . Esther K. . Rosseel . Peter M. J. . van der Bom . Johanna G. . Brand . Anneke . van der Meer . Nardo J. M. . van de Watering . Leo M. G. . 2017 . Does a Platelet Transfusion Independently Affect Bleeding and Adverse Outcomes in Cardiac Surgery? . Anesthesiology . 126 . 3 . 441–449 . 10.1097/ALN.0000000000001518 . 1528-1175 . 28092320.
  19. Baharoglu . M. Irem . Cordonnier . Charlotte . Al-Shahi Salman . Rustam . de Gans . Koen . Koopman . Maria M. . Brand . Anneke . de Haan . Rob J. . Roos . Yvo B. . PATCH Investigators . 2016-06-25 . Platelet transfusion versus standard care after acute stroke due to spontaneous cerebral haemorrhage associated with antiplatelet therapy (PATCH): a randomised, open-label, phase 3 trial . Lancet . 387 . 10038 . 2605–2613 . 10.1016/S0140-6736(16)30392-0 . 1474-547X . 27178479 . free.
  20. Ypma . Paula F. . van der Meer . Pieter F. . Heddle . Nancy M. . van Hilten . Joost A. . Stijnen . Theo . Middelburg . Rutger A. . Hervig . Tor . van der Bom . Johanna G. . Brand . Anneke . Kerkhoffs . Jean-Louis H. . PREPAReS Study Group . 2016-01-27 . A study protocol for a randomised controlled trial evaluating clinical effects of platelet transfusion products: the Pathogen Reduction Evaluation and Predictive Analytical Rating Score (PREPAReS) trial . BMJ Open . 6 . 1 . e010156 . 10.1136/bmjopen-2015-010156 . 2044-6055 . 4735127 . 26817642 . free.
  21. Schonewille . Henk . van de Watering . Leo M. G. . Oepkes . Dick . Lopriore . Enrico . Cobbaert . Christa M. . Brand . Anneke . 2020 . Prevalence of red-blood-cell and non-red-blood-cell-targeted autoantibodies in alloimmunized postpartum women . Vox Sanguinis . 115 . 8 . 783–789 . 10.1111/vox.12941 . 1423-0410 . 32458481 . free. 1887/3181244 . free .
  22. Schonewille . Henk . van Rood . Jon J. . Verduin . Esther P. . van de Watering . Leo M. G. . Brand . Anneke . 2019 . Exposure to non-inherited maternal antigens by breastfeeding affects antibody responsiveness . Haematologica . 104 . 2 . 263–268 . 10.3324/haematol.2018.199406 . 1592-8721 . 6355501 . 30213833 . free.
  23. Van der Zanden . Henk G. M. . Van Rood . Jon J. . Oudshoorn . Machteld . Bakker . Jack N. A. . Melis . Angelo . Brand . Anneke . Scaradavou . Andromachi . Rubinstein . Pablo . 2014 . Noninherited maternal antigens identify acceptable HLA mismatches: benefit to patients and cost-effectiveness for cord blood banks . Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation . 20 . 11 . 1791–1795 . 10.1016/j.bbmt.2014.07.011 . 1523-6536 . 25042738 . free.
  24. Brand . Anneke . 2016 . Immunological complications of blood transfusions . Presse Medicale (Paris, France: 1983) . 45 . 7-8 Pt 2 . e313–324 . 10.1016/j.lpm.2016.06.024 . 2213-0276 . 27499223.
  25. Verduin . Esther P. . Brand . Anneke . Middelburg . Rutger A. . Schonewille . Henk . 2015 . Female sex of older patients is an independent risk factor for red blood cell alloimmunization after transfusion . Transfusion . 55 . 6 Pt 2 . 1478–1485 . 10.1111/trf.13111 . 1537-2995 . 25846865.
  26. Schonewille . Henk . Honohan . Áine . van der Watering . Leo M. G. . Hudig . Francisca . Te Boekhorst . Peter A. . Koopman-van Gemert . Ankie W. M. M. . Brand . Anneke . 2016 . Incidence of alloantibody formation after ABO-D or extended matched red blood cell transfusions: a randomized trial (MATCH study) . Transfusion . 56 . 2 . 311–320 . 10.1111/trf.13347 . 1537-2995 . 26442648.
  27. Web site: In Memoriam Anneke Brand . The European Hematology Association (EHA) . 2021-11-21 . 2024-11-10.
  28. Garraud . Olivier . Brand . Anneke . Henschler . Reinhard . Vuk . Tomislav . Tissot . Jean-Daniel . 'European and Mediterranean Initiative in Transfusion Medicine' (EMITm) group . 2018 . Medical student education in transfusion medicine: Proposal from the "European and Mediterranean initiative in transfusion medicine" . Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis . 57 . 5 . 593–597 . 10.1016/j.transci.2018.09.002 . 1473-0502 . 30274948.
  29. Garraud . Olivier . Vuk . Tomislav . Brand . Anneke . de Angelis . Vincenzo . Tissot . Jean-Daniel . 2020 . Medical student education in transfusion medicine, part II: Moving forward to building up a "Know How" education program in transfusion medicine for under-graduate medical students . Transfusion and Apheresis Science: Official Journal of the World Apheresis Association: Official Journal of the European Society for Haemapheresis . 59 . 6 . 102879 . 10.1016/j.transci.2020.102879 . 1473-0502 . 32718832 . free.
  30. Web site: 2011-06-16 . Past winners . 2024-11-10 . BBTS.
  31. Web site: 2020-12-14 . Presidential Award Session: Anneke Brand . 2024-11-10 . The International Society of Blood Transfusion (ISBT).
  32. Web site: 2021-09-20 . AABB Congratulates 2021 AABB Award Recipients . 2024-11-10 . www.aabb.org.

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