Anne Osbourn Explained

Anne Osbourn
Birth Name:Anne Elisabeth Osbourn
Education:Bingley Grammar School
Alma Mater:Durham University
University of Birmingham
Workplaces:John Innes Centre
University of East Anglia
Sainsbury Laboratory
New Phytologist
Thesis Url:https://copac.jisc.ac.uk/id/45397984?style=html
Thesis Title:Host adaptation and variation in septoria nodorum
Thesis Year:1985
Fields:Natural products

Anne Elisabeth Osbourn [1] is a professor of biology and group leader at the John Innes Centre, where she investigates plant natural product biosynthesis. She discovered that in the plant genome, the genes involved with biosynthesis organise in clusters. She is also a popular science communicator, poet and is the founder of the Science, Art and Writing (SAW) Initiative. She was elected a member of the National Academy of Sciences in 2022.[2]

Early life and education

Osbourn grew up in West Yorkshire.[3] Her parents both studied and lectured English literature and her father served in the army during World War II. She became interested in plants as a child and she attended Bingley Grammar School graduating in 1979. She earned a bachelor's degree in botany at Durham University in 1982.[4] At this time, researchers worked out how to transform the Rhizobium nitrogen fixation genes into the bacterium Escherichia coli. Osbourn moved to the University of Birmingham for her doctoral studies on host adaptation in Septoria nodorum, supervised by Chris Caten. She has described the Salem State University educationalist Louise Swiniarksi as her 'anchor throughout my adult life'.

Research and career

Osbourn moved to Norwich in 1985 to work as a post-doctoral researcher at the John Innes Centre . In 1987 she joined The Sainsbury Laboratory as a Research Fellow, and she became a group leader in 1999. In 2005 she re-joined the John Innes Centre as a group leader, and was appointed head of the Department for Metabolic Biology in 2006.

Her early work looked at saponins and their role in plant defence.[5] [6] Osbourn studies how natural products interact with natural organisms.[7] In particular, she has worked on the biosynthesis of triterpene. She identified that metabolic pathways organise in operon-like clusters, which allowed her to develop a novel opportunity to discover natural product pathways through genome mining. The natural products include terpenes, which can be used in the pharmaceutical industry as well as food and manufacturing.[8] [9]

Her research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC).[10]

In 2006, Osbourn became an Honorary Professor[11] at the University of East Anglia. Since 2014 she has been the director of the OpenPlant Synthetic Biology Research Centre,[12] a BBSRC and EPSRC-funded Synthetic Biology Research Centre led jointly by the John Innes Centre and the University of Cambridge. The Cambridge-based Director is Professor Jim Haseloff and the formal lead is Professor Sir David Baulcombe.

She was the Director of the Norwich Research Park Industrial Biotechnology Alliance from 2013 to 2019.

As a group leader at the John Innes Centre she leads a research group working on plant natural products, their biosynthesis, function, mechanisms of metabolic diversification and metabolic engineering.

Public engagement

In 2004, Osbourn was appointed to the UEA Creative Writing Course as a Nesta dreamtime fellow. Here she wrote poetry about her life as a plant scientist.[13] [14] Since then Osbourn has become a popular science writer, and inspired by her own creative practice she founded the Science, Art and Writing (SAW) Trust in 2005.[15] [16] [17] The SAW Trust is an international charity that promotes innovation in science communication, and works with young people from elementary schools in initiatives which bring together scientists, writers and artists to explore creative science communication initiatives. The SAW Trust, working with educational bureaus and schools in China, has built an extensive educational programme for schools.[18] Over 1,000 children have now taken part in SAW projects in schools in China.

In 2016 Osbourn took part in an international exchange with the Vietnam Academy of Science and Technology.[19]

Honours and Editorial positions

Osbourn was elected to AcademiaNet in 2014.[20] She is an editor of the New Phytologist and is on the editorial board of Molecular Plant.

She has won various awards and honours, including the medal of the University of Helsinki in 2003. In 2018 she was elected a Fellow of the Linnean Society, and in 2019 Osbourn was elected as a Fellow of the Royal Society (FRS).[21] [22] She is the thirtieth research who has been elected Fellow from the John Innes Centre.

She was appointed Officer of the Order of the British Empire (OBE) in the 2020 New Year Honours for services to plant science.

Patents

Notes and References

  1. Web site: Anne Osbourn - Royal Society. Royalsociety.org. 20 April 2019.
  2. Web site: 2022 NAS Election .
  3. Web site: Professor Anne Osbourn. 21 November 2018. John Innes Centre. 18 April 2019.
  4. Web site: Gazette, XXVII (ns) including supplement . Durham University . 13 May 2019 . 45.
  5. Osbourn . Anne . 1996 . Saponins and plant defence — a soap story . Trends in Plant Science . 1 . 1 . 4–9 . 10.1016/S1360-1385(96)80016-1 . 1360-1385.
  6. Bouarab K, Melton R, Peart J, Baulcombe D, Osbourn A . 2002 . A saponin-detoxifying enzyme mediates suppression of plant defences . Nature . 418 . 6900 . 889–92 . 2002Natur.418..889B . 10.1038/nature00950 . 12192413 . 4348886.
  7. Web site: 23 April 2014 . Anne Osbourn at the 2014 DOE JGI Genomics of Energy & Environment Meeting . 19 April 2019 . Youtube.com . DOE Joint Genome Institute.
  8. Boutanaev AM, Moses T, Zi J, Nelson DR, Mugford ST, Peters RJ, Osbourn A . 2015 . Investigation of terpene diversification across multiple sequenced plant genomes . Proceedings of the National Academy of Sciences of the United States of America . 112 . 1 . E81-8 . 2015PNAS..112E..81B . 10.1073/pnas.1419547112 . 4291660 . 25502595 . free.
  9. Anon . 2005 . Multiple Campylobacter Genomes Sequenced . . 3 . 1 . e40 . 10.1371/journal.pbio.0030040 . 1545-7885 . 539341 . free .
  10. Web site: Portfolio Analyser . gow.bbsrc.ukri.org . 30 August 2022.
  11. Web site: Professor Anne Osbourne on the UEA website . March 15, 2022 . University of East Anglia (www.uea.ac.uk).
  12. Web site: Open Plant Management . OpenPlant.
  13. Osbourn A . Anne Osbourn . The New Phytologist . 208 . 1 . 23–5 . October 2015 . 26311283 . 10.1111/nph.13616 . free .
  14. Osbourn A . The poetry of science . Nature Reviews. Microbiology . 4 . 1 . 77–80 . January 2006 . 16357863 . 10.1038/nrmicro1321 . 27186317 .
  15. Web site: SAW antibiotics book launch, October 2017 » The SAW Trust. Sawtrust.org. 18 April 2019.
  16. Osbourn A . SAW: breaking down barriers between art and science . PLOS Biology . 6 . 8 . e211 . 2008 . 18752351 . 2525686 . 10.1371/journal.pbio.0060211 . free .
  17. Osbourn. Anne. 2009. A meeting place: The Science, Art and Writing initiative. Current Science. 97. 11. 1547–1554. 0011-3891. 24107294.
  18. Web site: SAW Trust Worldwide . March 15, 2022 . www.sawtrust.org.
  19. Web site: Professor Anne Osbourn Royal Society. Royalsociety.org. 18 April 2019.
  20. Web site: Prof. Anne Osbourn - AcademiaNet. Academia-net.org. 19 April 2019.
  21. Web site: 2019. Eastern Daily Press. Edp24.co.uk. Scientists honoured during 'golden age of discovery' at Norwich Research Park. Hill. Chris. 19 April 2019.
  22. Web site: Professor Anne Osbourn elected as Fellow of the Royal Society. 17 April 2019. John Innes Centre. 19 April 2019.
  23. Web site: 06.414 - Root-Specific Promoters PBL Technology. Pbltechnology.com. 19 April 2019.
  24. Web site: Enzymes involved in triterpene synthesis - Patent US8614369 - PubChem. Pubchem.ncbi.nlm.nih.gov. 19 April 2019.