| Anna Palaiologina | |
| Death Date: | 1320 |
| Full Name: | Greek, Modern (1453-);: Ἅννα Παλαιολογίνα |
| Dynasty: | Palaiologos |
| Father: | Michael IX Palaiologos |
| Mother: | Rita of Armenia |
Anna Palaiologina (died 1320; Greek, Modern (1453-);: Ἅννα Παλαιολογίνα) was a Byzantine princess and queen-consort (basilissa) of the Despotate of Epirus.
She was a daughter of the Byzantine co-emperor Michael IX Palaiologos and his wife, Rita of Armenia. Already in 1304, her hand was sought by the Epirote regent, Anna Palaiologina Kantakouzene, for her son Thomas I Komnenos Doukas; the marriage eventually took place in ca. 1307. When Thomas was murdered by his nephew, Nicholas Orsini, in 1318, the latter took Anna as his wife. She died in 1320.