Anita Corbett Explained

Anita Corbett
Birth Name:Anita Hargrave Corbett
Workplaces:Emory University
Alma Mater:Colgate University (BS)
Vanderbilt University (PhD)
Fields:mRNA processing
Polyadenylation
Gene expression
Intellectual disability
Thesis Title:Regulation of the catalytic cycle of topoisomerase II
Thesis Url:https://worldcat.org/en/title/30332920
Thesis Year:1992

Anita Hargrave Corbett is an American biochemist who is the Samuel C. Dobbs Professor in the Department of Biology at Emory University. Her research investigates the molecular basis for disease, the regulation of protein import and mRNA export. She is a Fellow of the American Association for the Advancement of Science and the American Society for Biochemistry and Molecular Biology.

Early life and education

As a high school student, Corbett took part in the National Science Bowl. She has said that her high school chemistry teacher made her believe she could be a chemist, and encouraged her to take AP Chemistry. She was an undergraduate student at Colgate University,[1] where she became interested in biochemistry, and studied the activation and inhibition of bovine carbonic anhydrase.[2] Corbett was a doctoral researcher at Vanderbilt University,[3] where she studied the regulation of topoisomerase II supervised by .[4]

Research and career

After her PhD, she moved to Harvard Medical School as a postdoctoral researcher with Pamela Silver.[5]

In 2003, Corbett was the first woman to be tenured in the Emory University School of Medicine. Her research investigates the regulation of biological processes, including the import of proteins and export of mRNA. She studies these processes using model systems of yeast, Drosophila and laboratory mice.[6] [7] It is well understood that disease is linked to mutations in genes encoding structural RNA exosome subunits. Corbett linked mutations in one particular subunit, EXOSC5, to poor clinical outcomes.[8] She has extensively investigated RNA-binding proteins, which are involved with various stages of gene expression.[9]

Awards and honors

Selected publications

Notes and References

  1. Web site: Anita H. Corbett, PhD . 2023-05-02 . biology.emory.edu.
  2. Rowlett . R S . Gargiulo . N J . Santoli . F A . Jackson . J M . Corbett . A H . 1991-01-15 . Activation and inhibition of bovine carbonic anhydrase III by dianions. . Journal of Biological Chemistry . en . 266 . 2 . 933–941 . 10.1016/S0021-9258(17)35263-8 . 0021-9258. free . 1898739 .
  3. Web site: Corbett goes the extra mile to support young scientists . 2023-05-02 . asbmb.org . en.
  4. PhD. Anita Hargrave. Corbett . Regulation of the catalytic cycle of topoisomerase II . 30332920 . 1992. en. .
  5. Web site: Nature Awards give mentors the recognition, funding, and 'street cred' they need . Anon. 2019 . 2023-05-02 . springernature.com.
  6. Web site: Professor Anita H. Corbett . 2023-05-02 . rnasociety.org.
  7. Corbett . Anita H. . 2015-04-01 . A long and winding road to the RNA world . RNA . en . 21 . 4 . 590–591 . 10.1261/rna.049841.115 . 1355-8382 . 25780152. 4371294 .
  8. Slavotinek . Anne . Misceo . Doriana . Htun . Stephanie . Mathisen . Linda . Frengen . Eirik . Foreman . Michelle . Hurtig . Jennifer E. . Enyenihi . Liz . Sterrett . Maria C. . Leung . Sara W. . Schneidman-Duhovny . Dina . Estrada-Veras . Juvianee . Duncan . Jacque L. . Haaxma . Charlotte A. . Kamsteeg . Erik-Jan . 2020-08-03 . Biallelic variants in the RNA exosome gene EXOSC5 are associated with developmental delays, short stature, cerebellar hypoplasia and motor weakness . Human Molecular Genetics . 29 . 13 . 2218–2239 . 10.1093/hmg/ddaa108 . 1460-2083 . 7399534 . 32504085.
  9. Web site: Anita Corbett . 2023-05-02 . biology.emory.edu.
  10. Web site: Laney Graduate School announces Eleanor Main Graduate Mentor Awards Emory University Atlanta GA . 2023-05-02 . news.emory.edu . en.
  11. Web site: Emory faculty named 2022 fellows of the American Association for the Advancement of Science Emory University Atlanta GA . 2023-05-02 . news.emory.edu . en.
  12. Web site: 2022 ASBMB fellows named . 2023-05-02 . asbmb.org . en.
  13. Web site: 2022 RNA Society Award for Excellence in Inclusive Leadership . 2023-05-02 . rnasociety.org.