Anisodamine Explained

Anisodamine, also known as 7β-hydroxyhyoscyamine, is an anticholinergic and α₁ adrenergic receptor antagonist used in the treatment of acute circulatory shock in China.^[1] It is given orally or by injection, as a racemic mixture (racanisodamine) or as a hydrobromide salt.^[2] Eye drops at 0.5% concentration for slowing the progression of myopia is also available in China.^[3]

Anisodamine is a naturally occurring tropane alkaloid found in some plants of the family Solanaceae including Datura.^{[4] [5]} Its Mandarin Chinese name Chinese: 山莨菪[[wikt:碱|碱]] is given after Anisodus tanguticus .^[6]

See also

• Anisodine
• Atropine, used for similar cardiac and optamological purposes elsewhere
• Hyoscyamine

Notes and References

1. Varma DR, Yue TL . Adrenoceptor blocking properties of atropine-like agents anisodamine and anisodine on brain and cardiovascular tissues of rats . . 87 . 3 . 587–94 . March 1986 . 2879586 . 1916562 . 10.1111/j.1476-5381.1986.tb10201.x.
2. Web site: Pharmacopoeia Search: "山莨菪碱". https://archive.today/20171203014251/http://www.yaobiaozhun.com/yd2015/index.php?k=%E5%B1%B1%E8%8E%A8%E8%8F%AA%E7%A2%B1. dead. 2017-12-03. 中国药典.
3. 消旋山莨菪碱滴眼液防治少年儿童假性近视的疗效分析. 国际医药卫生导报. 2008. 14. 15. 67–68. 10.3760/cma.j.issn.1007-1245.2008.15.027. zh-cn. 2017-12-03. 2023-03-27. https://web.archive.org/web/20230327142238/http://med.wanfangdata.com.cn/Paper/Detail?id=PeriodicalPaper_gjyywsdb200815027. live.
4. Ye N, Li J, Gao C, Xie Y . Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide . . 36 . 16 . 2698–702 . August 2013 . 23868645 . 10.1002/jssc.201300304 .
5. Zhang WW, Song MK, Cui YY . Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine . Neuroscience Letters . 443 . 3 . 241–5 . October 2008 . 18672024 . 10.1016/j.neulet.2008.07.048 . 2730169 . etal.
6. Web site: 消旋山莨菪碱. 中国药典. 3 December 2017. https://archive.today/20171203013717/http://www.yaobiaozhun.com/yd2015/view.php?v=txt&id=4045. 2017-12-03. zh-CN.