Anicequol Explained

Anicequol (developmental code names NGA0187, NGD-187)^[1] is a naturally occurring ergostane steroid produced by Acremonium sp. TF-0356 which has nerve growth factor-like neurotrophic activity.^{[2] [3] [4]} It was under investigation by Taisho Pharmaceutical in Japan for the treatment of cognitive disorders in the 1990s, but development was discontinued and the drug was never marketed.^[5]

Chemistry

See also: List of neurosteroids.

See also

• BNN-20
• BNN-27
• Sarsasapogenin

External links

• NGD-187 - AdisInsight

Notes and References

1. Gao SS, Li XM, Li CS, Proksch P, Wang BG . Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S . Bioorg. Med. Chem. Lett. . 21 . 10 . 2894–7 . 2011 . 21489788 . 10.1016/j.bmcl.2011.03.076 . Anicequol (3) was independently isolated from Acremonium sp. TF-0356 and was assigned the trivial name NGA0187..
2. Nozawa Y, Sakai N, Matsumoto K, Mizoue K . A novel neuritogenic compound, NGA0187 . J. Antibiot. . 55 . 7 . 629–34 . 2002 . 12243452 . 10.7164/antibiotics.55.629. free .
3. Hua Z, Carcache DA, Tian Y, Li YM, Danishefsky SJ . The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187 . J. Org. Chem. . 70 . 24 . 9849–56 . 2005 . 16292815 . 10.1021/jo051556d .
4. Williams B, Dwyer DS . Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor . J. Neurochem. . 110 . 6 . 1876–84 . 2009 . 19627449 . 2753211 . 10.1111/j.1471-4159.2009.06291.x .
5. Web site: NGD 187 - AdisInsight. adisinsight.springer.com.