Angiomotin-like protein 1 explained

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.^{[1] [2]}

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.^[2]

Further reading

• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination. . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Bratt A, Wilson WJ, Troyanovsky B . Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains. . Gene . 298 . 1 . 69–77 . 2003 . 12406577 . 10.1016/S0378-1119(02)00928-9 . etal.
• Wiemann S, Arlt D, Huber W . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . etal.
• Patrie KM . Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. . Biochim. Biophys. Acta . 1745 . 1 . 131–44 . 2005 . 16019084 . 10.1016/j.bbamcr.2005.05.011 .
• Mehrle A, Rosenfelder H, Schupp I . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . etal.

Notes and References

1. Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y . JEAP, a novel component of tight junctions in exocrine cells . J Biol Chem . 277 . 7 . 5583–7 . Feb 2002 . 11733531 . 10.1074/jbc.M110154200 . free .
2. Web site: Entrez Gene: AMOTL1 angiomotin like 1.