Angelicin synthase explained

Angelicin synthase
Ec Number:1.14.13.115

Angelicin synthase (CYP71AJ4 (gene)) is an enzyme with systematic name (+)-columbianetin,NADPH:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:

(+)-columbianetin + NADPH + H+ + O2

\rightleftharpoons

angelicin + NADP+ + acetone + 2 H2O

Angelicin synthase is a P450 monooxygenase enzyme.

Notes and References

  1. Larbat R, Hehn A, Hans J, Schneider S, Jugdé H, Schneider B, Matern U, Bourgaud F . Isolation and functional characterization of CYP71AJ4 encoding for the first P450 monooxygenase of angular furanocoumarin biosynthesis . The Journal of Biological Chemistry . 284 . 8 . 4776–85 . February 2009 . 19098286 . 10.1074/jbc.M807351200 . free .

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